肿瘤相关成纤维细胞对肿瘤免疫调控作用的研究进展

Progress on cancer associated fibroblasts in tumor immunoregulation

肿瘤相关成纤维细胞(CAF)是肿瘤微环境中的重要组分,它通过分泌多种生长因子、趋化因子以及蛋白酶,调控肿瘤微环境中固有免疫细胞和适应性免疫细胞的募集和功能的发挥。此外,CAF分泌的胞外基质在塑造肿瘤微环境免疫抑制特性以及低氧形成的过程中也发挥着重要的促进作用。本文综述了肿瘤微环境中CAF对固有免疫细胞和适应性免疫细胞的浸润以及功能发挥的调控机制,同时针对以CAF为靶细胞进行药物开发的相关问题进行了展望,为进一步研究CAF的功能和临床应用提供科学依据。

Cancer associated fibroblasts(CAFs) are important components of the tumor microenvironment.Through secreting of multiple growth factors,cytokines and proteases,CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment.In addition,extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment.Here,we review the progress on CAFs in regulation of immune cells and tumor immunity.