脂质组学策略在脑病相关领域的应用进展

Application Progress of Lipidomics Strategy in Brain Diseases

脂质组学是一门借用现代化分析技术研究疾病发生与治疗等状态下脂质水平的新兴学科,可用于识别脂质代谢途径、构建病理生理学脂质代谢网络、挖掘临床诊断标志物并监测疾病进程。大脑是生命活动中枢,也是脂质含量最高的器官,脂质代谢异常可诱发多种脑部疾病,脂质组学的应用为脑病的早期诊断、早期干预提供了思路。综述脂质组学在卒中、神经退行性疾病、脑外伤、脑癌等脑病中的应用及新进展,旨在为疾病的预防及治疗提供参考依据。

Lipidomics is an emerging discipline that uses modern analytical techniques to study lipid levels during disease development and treatment. It could be used to identify the pathways of lipid metabolism, build the network of lipid metabolism under normal or disease conditions, discover diagnostic biomarkers and monitor disease progression. Brain, the center system of organism, is the organ with the highest content of lipids. Disordered lipid metabolism could trigger a variety of brain diseases. Thus, comprehensive lipid profiling provides insight into the prevention and early diagnosis of encephalopathy. This paper focused on the recent advances and applications of lipidomics for brain diseases such as stroke, neurodegenerative disease, brain trauma, and brain tumor, aiming to provide reference for disease prevention and treatment.