摘要
肥胖及其相关并发症患病率逐年上升,相较于传统治疗方式,代谢性手术治疗肥胖及代谢性疾病疗效确切。术后肠道菌群改变可通过胆汁酸、短链脂肪酸、氨基酸、脂多糖、氧化三甲胺及神经递质等多种代谢物协助减轻体重,改善代谢,本文总结了代谢性手术中肠道菌群参与其中的可能机制。
Obesity has become a global epidemic and is accompanied by a tremendously rising prevalence of its associated comorbidities.Bariatric surgery is currently the most effective approach to treat obesity and metabolic disturbances compared to traditional interventions.The present review focuses on the potential mechanisms of gut microbiota mediating the improvement in body weight and metabolism after bariatric surgery,including the change of bile acids,short-chain fatty acids,amino acids,lipopolysaccharides,trimetlylamine oxide as well as neurotransmitters.
作者
陈于菲
洪洁
Chen Yufei;Hong Jie(Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Shanghai Clinical Center for Endocrine and Metabolic Disease,Ruijin Hospital,Shanghai Jiaotong University School of Medicine, Shanghai 200025,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2019年第1期1-6,共6页
Chinese Journal of Endocrinology and Metabolism
基金
国家重点研发计划资助项目(2018YFC2313800)
国家自然科学基金项目(81471060、81870582).
关键词
代谢性手术
肥胖
肠道菌群
Metabolic surgery
Obesity
Gut microbiota
