泮托拉唑联合维生素C治疗2型糖尿病合并胃溃疡患者的临床观察

Efficacy of pantoprazole combined with vitamin C in the treatment of type 2 diabetes mellitus with gastric ulcer

目的探讨泮托拉唑联合维生素C治疗2型糖尿病合并胃溃疡患者的疗效及对相关实验室指标的影响。方法确诊的2型糖尿病合并胃溃疡患者54例,按随机数字表法将所有入组患者分为观察组(泮托拉唑+维生素C)和对照组(泮托拉唑),检测并比较2组患者治疗后FPG、HbA_(1C)、TC、TG、TyG指数、胃溃疡疗效及生活质量评分。结果治疗后观察组FPG、HbA_(1c)、TC、TG、TyG指数均优于对照组(P <0. 05)。治疗后观察组的胃溃疡治疗总有效率显著高于对照组,差异有统计学意义(P <0. 05); 2组患者生活质量评分均高于本组治疗前,且治疗后观察组患者的生活质量评分显著高于对照组,差异有统计学意义(P <0. 05)。结论托拉唑联合维生素C用于治疗2型糖尿病合并胃溃疡可达到较好的疗效,并在血糖、血脂及患者生活质量的改善方面有一定优势。

Objective To investigate the efficacy and the related indicators of pantoprazole combined with vitamin C in the treatment of patients with type 2 diabetes complicated with gastric ulcer. Methods A total of 124 patients with type 2 diabetes complicated with gastric ulcer who were treated in our hospital were enrolled. All patients were divided into the observation group( pantoprazole+ Vitamin C) and the control group( Pantoprazole),according to the random number table. FPG,HbA1c,TC,TG,TyG index,Gastric ulcer treatment efficiency and the quality of life scores between two groups were measured and analyzed after treatment. Results After treatment,the FPG,HbA1c,TC,TG and TyG index in the observation group were better than those in the control group( P < 0. 05). After treatment,the total effective rate of gastric ulcer in the observation group was significantly higher than that in the control group( P <0. 05). The quality of life scores of the two groups were higher than that before treatment. The quality score of the patients in the observation group was significantly higher than the control group after treatment( P < 0. 05). Conclusion Pantoprazole combined with vitamin C for the treatment of type 2 diabetes with gastric ulcer can achieve better curative effect,and has certain advantages in the improvement of blood sugar,blood lipids,gastric pH and the quality of life.