糖尿病肾病患者生物节律紊乱的中医证型及影响因素研究

Study on Traditional Chinesse Medicine Syndrome Type and Influencing Factors of Diabetic Nephropathy Patients with Biologic Rhythm Disorder

目的:观察糖尿病肾病患者生物节律紊乱的中医证型及影响因素。方法:随机选择2014年7月～2017年7月伴随生物节律紊乱的未透析前DN患者86例,随访患者1年,将患者是否转为透析期作为分组标准,分成透析组27例,未透析组患者59例,每隔3个月对患者进行PSQI评分和中医症候评分,观察两组患者评分变化情况,观察生物节律紊乱与糖尿病肾病患者中医证型变化的相关性。结果:两组患者来诊时和随访3个月后PSQI评分均无明显差异(P>0. 05),随访6个月、9个月、12个月透析组患者PSQI评分明显高于未透析组,且具有统计学差异(P<0. 05);两组患者来诊时、随访3个月、随访6个月的中医症候评分均无统计学差异(P>0. 05),随访9个月、12个月透析组患者中医症候评分明显高于未透析组,且具有统计学差异(P<0. 05);以患者症候评分为因变量,以患者PSQI评分为自变量,对患者进行回归分析,结果发现患者症候评分与PSQI评分两者呈正相关,具有统计学意义。结论:糖尿病肾病患者病情进展与患者生物节律紊乱呈正相关,患者生物节律紊乱越严重,糖尿病肾病进展越快。

Objective:To observe the TCM syndrome type and influencing factors of diabetic nephropathy patients with biological rhythm disorder.Methods:Randomly selected from July 2014 to July 2017 with the biological rhythm before dialysis in86 patients with DN,patients were followed up for 1years,would be turned into dialysis patients as grouping criteria,divided into dialysis group 27 cases,59cases of patients with non dialysis group,every 3months for patients with PSQI score and TCM syndrome,observing the two groups of patients were observed,observation of the relationship between circadian rhythm disorders and diabetic nephropathy in patients with TCM syndrome type change.Results:There were no significant difference between the groups of patients to the diagnosis and follow-up of 3months after the PSQI score(P>0.05),follow-up of 6months,9months,12 months of dialysis patients PSQI score was significantly higher than that in non dialysis group,and had statistically significant difference(P< 0.05).There were no statistically significant differences between the two groups to visit and followed up for3 months and 6months of follow-up symptom score(P> 0.05),were followed up for 9months and 12 months of dialysis patients TCM syndrome was significantly higher than that in non dialysis group,and had statistically significant difference(P<0.05).In patients with symptom score as the dependent variable,in patients with a PSQI score for patients as the independent variables.By regression analysis,found that patients with symptom score and PSQI score both were positively correlated with statistical significance.Conclusion:The progression of diabetic nephropathy is positively correlated with the disturbance of circadian rhythm.The more serious the disorder of biological rhythm is,the faster the progression of diabetic nephropathy is.