知识图谱视角下埃博拉病毒研究态势分析

Progress in researches on Ebola virus: a mapping knowledge domain analysis

目的了解国际埃博拉病毒领域研究现状和趋势,为我国新发和烈性传染病防控及生物安全提供情报参考。方法利用文献计量法和科学知识图谱分析,对2007——2017年埃博拉病毒这一代表性的新发和烈性传染病原领域的研究热点及发展趋势进行分析。结果共检索到论文4 086篇,论文数量增长分为3个阶段:1977——1994、1995——2013和2014——2017年。美国、英国、德国、加拿大、法国分别位居该领域前5名,并相互间合作紧密;我国论文总量排名第6,总被引和篇均被引频次分别排名第9和第10位。目前埃博拉病毒领域的6个研究热点:病毒流行病学;病毒检测方法;遗传机制研究;病原学和入侵机制;致病机理和宿主免疫反应;治疗和药物研发。结论近年来世界尤其是西方发达国家对埃博拉病毒的研究不断加强,我国在相关领域处于劣势,需考虑新疫情防控及可能带来的国家生物安全风险。

Objective To examine the profile and trend of researches on Ebola virus for providing references to the control of emerging and severe infectious diseases and biosafety in China.Methods We searched Ebola virus-related studies published till 2017 and analyzed hotspots and trends of the researches using bibliometrics and mapping knowledge domain method.Results Totally 4 086 papers were included in the analysis. Three periods with different increment in number of papers published yearly were 1977-1994, 1995-2013, and 2014-2017, with a great increment in recent years. The top five countries with a higher number of published studies are the United States, Britain, Germany, Canada and France and there were close cooperations for many of the published studies among the five countries. China is the sixth country for more published studies, ninth for the number of studies cited and tenth for the mean citation frequency of a published study. The included studies mainly involved following 6 academic disciplines:virus epidemiology, virus detection, genetic mechanism, etiology and transmission mechanism, pathogenesis and host immune response, and treatment and development of medicine.Conclusion The research on Ebola virus has been increased continuously during the past decade in the world, especially in western developed countries. However, China is at a backward situation in the research field and it is necessary to consider the possible risk of national biosafety associated with the prevention and control of new infectious epidemics.