抗生素导致相关性心律失常的研究进展

Advances in the Study of Antibiotics-related Arrhythmias

抗生素是一类用于抑制细菌生长或杀死细菌的药物,临床广泛用于预防和治疗各种感染性疾病。研究表明抗生素具有一些胃肠道反应、肝、肾损害、血液系统等副作用。而近年研究发现有些抗生素也具有严重心脏副作用,尤其是能导致尖端扭转型室性心动过速(Tdp)的恶性心律失常。本文针对最常见的致心律失常抗生素大环内酯类、氟喹诺酮类药物导致TdP的电生理机制、流行病学和其它并存危险因素等方面进一步阐述。

Antibiotics are a class of drugs used to inhibit bacterial growth or kill bacteria,and widely used in clinical prevention and treatment of various infectious diseases.Studies have shown that antibiotics have some adversed effects such as gastrointestinal reactions,liver and kidney damage,and blood system disorder.In recent years,some antibiotics have been found to have serious cardiac side effects,especially malignant arrhythmias which can cause torsade de pointes (Tdp).The electrophysiological mechanism,epidemiology and other coexisting risk factors of TdP caused by the most common arrhythmogenic antibiotics,macrolides and fluoroquinolones,are discussed in this paper.