MiR-224在结直肠癌中的研究进展

Research progress of miR-224 in colorectal cancer

结直肠癌是人类的第三大常见癌症,严重危害人类健康。microRNAS(miRNAs)影响结直肠癌的发生、发展,miR-224作为miRNA中重要的一员,通过作用于下游靶点,调控结直肠癌的迁移、增殖、侵袭转移和耐药,影响结直肠癌的预后。因此,本文对miR-224及靶点在结直肠癌中的作用作一综述,为结直肠癌在细胞、分子水平的诊治提供新思路。

Colorectal cancer is the third most common cancer in humans and poses a serious threat to human health.MicroRNAs (miRNAs)affected the mechanism of occurrence and development of colorectal cancer.As an important member of miRNA,miR-224 modulates the migration,proliferation,metastases and drug resistance of colorectal cancer by acting on its downstream targets.The expression of miR-224 affects the prognosis of colorectal cancer.Therefore,this review summarizes the role of miR-224 and its downstream targets in colorectal cancer,it may provide a new method for diagnosis and treatment to colorectal cancer at the cellular and molecular level.