固本泄浊方治疗无症状高尿酸血症的疗效及其对hs-CRP及血脂的影响

The Influence on Clinical Efficacy, hs-CRP and Blood Lipids in Asymptomatic Hyperuricemia by Guben Xiezhuo Prescription(固本泄浊方)

目的:观察固本泄浊方治疗无症状高尿酸血症患者的疗效及其对hs-CRP及血脂的影响。方法:将90例无症状高尿酸血症患者随机分成中药组、西药组、对照组,每组30例,治疗8周为1个疗程。观察3组患者治疗前后血清UA、hs-CRP、甘油三酯(TG)、胆固醇(TC)水平,及治疗前后患者及停药8周后患者血尿酸变化。结果:治疗后,中药组、西药组血尿酸水平较治疗前降低,且均低于对照组,差异均有统计学意义(P<0.05),中药组与西药组比较,差异无统计学意义(P>0.05)。停药8周后,中药组血尿酸水平低于西药组,差异有统计学意义(P<0.05)。中药组、西药组总有效率比较,差异无统计学意义(P>0.05),两组总有效率与对照组比较,差异均有统计学意义(P<0.05)。停药8周后,中药组总有效率优于西药组,差异有统计学意义(P<0.05)。中药组患者治疗后hs-CRP、TG、TC水平较治疗前下降,差异均有统计学意义(P<0.05);西药组患者治疗后hs-CRP水平较治疗前降低,差异有统计学意义(P<0.05),TG、TC水平较治疗前比较,差异均无统计学意义(P>0.05);对照组患者治疗前后hsCRP、TG、TC水平比较,差异均无统计学意义(P>0.05)。结论:固本泄浊方可有效降低高尿酸血症患者血尿酸水平,还能降低患者hs-CRP、TC、TG水平,减轻炎症反应。

[Abstrat] Objective: To observe the influence on efficacy, hs-CRP and blood lipids in asymptomatic hyperuricemia patients by Guben Xiezhuo prescription(GXP). Methods: A total of 90 patients with asymptomatic hyperuricemia were randomly assigned to Chinese medicine group, Western medicine group and control group, 30 cases in each group. Eight weeks consisted of one course of treatment. The hs-CRP, TG and TC data were statistically analyzed before and after treatment. The uric acid data were statistically analyzed before and after treatment and after 8 weeks of discontinuation. Results: The blood uric acid decreased in the Chinese medicine group and Western medicine group after treatment, and the Chinese medicine group and Western medicine group showed lower blood uric acid than control group(P<0.05);There was no statistical difference on blood uric acid between Chinese medicine group and Western medicine group(P>0.05). Drug discontinuance after 8 weeks, Chinese medicine group showed lower uric acid levels than Western medicine group(P<0.05);There was no statistical difference on total effective rate between Chinese medicine group and Western medicine group(P >0.05),while the above two groups showed better total effective rate than control group(P<0.05). Drug discontinuance after 8 weeks, Chinese medicine group showed better total effective rate than Western medicine group(P<0.05).The levels of hs-CRP, TG and TC were decreased after treatment in Chinese medicine group and the difference was statistically significant(P<0.05);The levels of hs-CRP decreased after treatment in Western medicine group and the difference was statistically significant(P<0.05), while there was no significant change in TG and TC before and after treatment. There was no statistical difference on levels of hs-CRP, TG and TC between before and after treatment in control group(P>0.05). Conclusion: Guben Xiezhuo prescription could effectively reduce the levels of uric acid, hs-CRP, TC and TG, and relieve inflammatory response in hyperuricemia patients.