摘要
目的观察术前外周血中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对较低级别胶质瘤患者临床预后的影响。方法共纳入经术后病理证实的初发较低级别胶质瘤病例242例,收集其临床资料及生存资料。采用Kaplan-Meier法计算生存率,用Log-rank进行单因素生存分析。Cox模型比例风险评估做多因素分析。结果NLR和PLR的最佳cut-off值分别为1.95和197.22。NLR≤1.95和NLR>1.95两组的3年和5年生存率分别为0.809比0.649、0.675比0.462,两者差异有统计学意义(P<0.01);PLR≤197.22和PLR>197.22两组3年和5年生存率分别为0.756比0.549、0.599比0.275,两者差异有统计学意义(P<0.01),高的NLR和PLR与较低级别胶质瘤患者差的临床预后明显相关。NLR(P<0.01)、PLR(P<0.05)是影响较低级别胶质瘤患者临床预后的独立危险因素。结论高的NLR和PLR预示较低级别胶质瘤患者较差的临床预后。
Objective To investigate the prognostic values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with lower-grade gliomas. Methods 242 patients with pathological diagnosis of lower-grade gliomas (WHO Ⅱ and WHOⅢ) were enrolled in the study, and relevant data were collected. Kaplan-Meier method was used to calculate the survival rates. Cox regression model was used to conduct multivariate analysis.Results The best cut-off values for NLR and PLR were 1.95 and 197.22. The 3-year and 5-year survival rate for NLR≤1.95 and NLR>1.95 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). The 3-year and 5-year survival rate for PLR≤197.22 and PLR>197.22 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). High NLR (P<0.01) and PLR (P<0.05) were independent prognostic factors influencing the survival of lower-grade gliomas.Conclusion NLR and PLR were potential factors for predicting the survival of lower-grade gliomas.
作者
周金桥
湛允波
刘献志
张振宇
Zhou Jinqiao;Zhan Yunbo;Liu Xianzhi;Zhang Zhenyu(Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2019年第1期144-146,共3页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(81702465)
河南省科技攻关计划项目(172102310648)
河南省医学科技攻关计划项目(201602058)
河南省卫生系统出国研修计划项目(2016008).