术前外周血中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对较低级别胶质瘤患者临床预后的影响

Effect of preoperative peripheral blood neutrophil -to -lymphocyte ratio and platelet -to -lympho- cyte ratio on clinical prognosis of patients with lower -grade glioma

目的观察术前外周血中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)对较低级别胶质瘤患者临床预后的影响。方法共纳入经术后病理证实的初发较低级别胶质瘤病例242例,收集其临床资料及生存资料。采用Kaplan-Meier法计算生存率,用Log-rank进行单因素生存分析。Cox模型比例风险评估做多因素分析。结果NLR和PLR的最佳cut-off值分别为1.95和197.22。NLR≤1.95和NLR>1.95两组的3年和5年生存率分别为0.809比0.649、0.675比0.462,两者差异有统计学意义(P<0.01);PLR≤197.22和PLR>197.22两组3年和5年生存率分别为0.756比0.549、0.599比0.275,两者差异有统计学意义(P<0.01),高的NLR和PLR与较低级别胶质瘤患者差的临床预后明显相关。NLR(P<0.01)、PLR(P<0.05)是影响较低级别胶质瘤患者临床预后的独立危险因素。结论高的NLR和PLR预示较低级别胶质瘤患者较差的临床预后。

Objective To investigate the prognostic values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with lower-grade gliomas. Methods 242 patients with pathological diagnosis of lower-grade gliomas (WHO Ⅱ and WHOⅢ) were enrolled in the study, and relevant data were collected. Kaplan-Meier method was used to calculate the survival rates. Cox regression model was used to conduct multivariate analysis.Results The best cut-off values for NLR and PLR were 1.95 and 197.22. The 3-year and 5-year survival rate for NLR≤1.95 and NLR>1.95 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). The 3-year and 5-year survival rate for PLR≤197.22 and PLR>197.22 subgroups were 0.809 vs. 0.649 and 0.675 vs. 0.462, respectively (P<0.01). High NLR (P<0.01) and PLR (P<0.05) were independent prognostic factors influencing the survival of lower-grade gliomas.Conclusion NLR and PLR were potential factors for predicting the survival of lower-grade gliomas.