肿瘤患者血小板抗体筛查的影响因素分析

Influencing factor analysis of platelet antibody screening in tumor patients

目的了解肿瘤患者血小板抗体阳性的发生情况,探讨相关影响因素。方法统计描述河南省肿瘤医院2015年1月—2016年6月期间住院肿瘤患者血小板抗体阳性分布状况,分析血小板抗体阳性与性别、年龄、疾病、输血和生育等因素的关系。结果 2 022例血小板抗体检测患者中阳性181例(阳性率8. 95%);男性患者70例(阳性率6. 47%);女性患者111例(阳性率11. 81%),性别间分布差异具有统计学意义(P<0. 05)。各年龄段肿瘤患者的血小板抗体筛查阳性率差异不具有统计学意义(男性P>0. 05;女性P>0. 05)。有输血史患者的血小板抗体阳性率为11. 55%,高于无输血史患者的阳性率3. 24%(P<0. 05)。血液肿瘤患者和其他系统肿瘤患者的血小板抗体阳性率分别为10. 02%和7. 04%(P<0. 05)。有生育史和有输血史的女性患者血小板抗体阳性率分别为13. 13%和14. 97%,分别高于无生育史的4. 29%和无输血史的4. 04%(P<0. 05)。结论肿瘤患者的血小板抗体阳性率低于以往文献报道的结果,既往有输血史、生育史的女性肿瘤患者血小板抗体阳性率高。

Objective To understand the occurrence of positive platelet antibody in tumor patients,and to explore the relevant influencing factors. Methods The positive distribution of platelet antibodies in tumor patients recorded from January2015 to June 2016 in Henan Provincial Cancer Hospital was statistically described,and the relationship between platelet antibody positivity and gender sex,age,disease,blood transfusion and fertility were analyzed. Results There were 181 cases with positive platelet antibody among the 2022 tumor patients,the positive rate was 8. 95%. Among them,70 cases were male(positive rate 6. 47%) and 111 cases were female(positive rate 11. 81%). The difference in gender distribution was statistically significant(P<0. 05). There was no statistically significant difference in the positive rates of platelet antibody among tumor patients of all ages.(male P > 0. 05;female P > 0. 05). The positive rate of platelet antibody in patients with blood transfusion history was 11. 55%,which was higher than that of the patients without history of blood transfusion(3. 24%).The difference between the two was statistically significant(P<0. 05). The positive rate of platelet antibody in patients with hematological tumors and other types of tumors were 10. 02% and 7. 04%,respectively(P<0. 05). The positive rate of platelet antibody in women with birth history and blood transfusion history were 13. 13% and 14. 97%,respectively,which were higher than the 4. 29% of no birth history and 4. 04% of no blood transfusion history(P<0. 05). Conclusion The positive rate of platelet antibody in tumor patients in this study was lower than that reported in the literature. Female tumor patients with a history of blood transfusion and birth have a higher positive rate of platelet antibody.