裴氏着色芽生菌病1例

A Case of Chromoblastomycosis Caused by Fonsecaea Pedrosoi

患者男,61岁。右下肢结节反复破溃20余年。皮肤科情况:右下肢大片环状暗红色斑块,中央伴萎缩,部分斑块上结痂,色素沉着。皮损组织病理示:真皮内混合炎症细胞及多核巨细胞浸润,其中可见硬壳小体。经ITS扩增测序鉴定为裴氏着色霉,诊断为裴氏着色芽生菌病,予以伊曲康唑胶囊口服治疗后好转。

A 61-year-old male who suffered from recurrent nodules and ulceration of right lower extremity for more than 20 years is reported.Physical examination revealed large annular dark red plaques on the right lower extremity with atrophy in the center,as well as scab and pigmentation on some plaques.Histopathology showed infiltration of mixed inflammatory cells and multinucleated giant cells in the dermis,in which sclerotic bodies were observed.It was identified as Fonsecaea pedrosoi through ITS amplification and sequence analysis,which was diagnosed as chromoblastomycosis.The symptoms were significantly improved aftertreatment with itraconazole capsules.