社区中老年人群颈动脉粥样硬化与血浆致动脉粥样硬化指数的关系及其危险因素研究

Research on the correlation between the AIP and CAS in the middle-aged and the elderly in the community and on the risk factors

目的探究社区中老年人群血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)与颈动脉粥样硬化(carotid arteriosclerosis,CAS)之间的关系,同时研究颈动脉粥样硬化的各项危险因素。方法收集来本社区卫生服务中心进行体检的中老年人群(年龄> 45岁) 835例,纳入研究者576例,收集经颈动脉彩色多普勒超声检查诊断为颈动脉粥样硬化者(CAS)者255例作为病例组,无CAS者321例作为对照组。对2组受试者进行血脂检查、肝功能、肾功能、血糖、血压、腹部B超等常规检查。同时问卷调查记录研究对象的一般健康情况并统计分析。结果 CAS组在BMI、血压、空腹血糖、尿酸等指标上与对照组比较差异有统计学意义,CAS组的AIP指数明显高于正常对照组。通过对18种因素调查,其中7种因素差异有统计学意义(均P <0. 05),分别为脂肪肝史(OR=2. 337)、高脂血症史(OR=4. 572)、BMI指数> 24 kg/m2(OR=2. 801)、糖尿病史(OR=11. 133)、每日进食蔬菜量≤500 g(OR=3. 095)、高血压史(OR=3. 421)、经常运动(OR=0. 076),其中经常运动为其保护因素。结论在社区中老年人群中,AIP与CAS密切相关,AIP可有效预测动脉粥样硬化的情况。颈动脉粥样硬化同时与高血压、糖尿病、BMI、生活方式等都息息相关。

Objective This research mainly aims to explore the correlation between the atherogenic index of plasma( AIP) and carotid arteriosclerosis( CAS) in the middle-aged and the elderly in the community,and to study various risk factors of CAS. Methods A total of 835 middle-aged and aged people( > 45 years old) were collected from those accepted physical examination in the community health service center,including 255 cases diagnosed with CAS by the carotid artery color Doppler flow imaging as the case group,while 321 cases without CAS as the control group. Two groups of subjects were given routine inspections such as blood lipid,liver function and renal function,blood glucose,and blood pressure examination,and abdominal B ultrasound. And the patients also filled the questionnaires and recorded the health of the objects. Results There were statistical differences between CAS group and the control group in BMI,blood pressure,fasting blood glucose,uric acid,etc. AIP index of the CAS group was significantly higher than that of normal control group. Via 18 sets of questionnaire survey,7 factors showed statistical differences( all P < 0. 05),namely history of fatty liver( OR = 2. 337),history of hyperlipidemia( OR = 4. 572),BMI > 24( OR = 2. 801),history of diabetes( OR = 11. 133),daily vegetable consumption≤500 g( OR = 3. 095),history of hypertension( OR = 3. 421),and regular exercise( OR = 0. 076),where regular exercise as the protection factor. Conclusion Our research results show that AIP is closely related with CAS in the middle-aged and the elderly in the community and AIP can be used for the measurement of LDL-C diameter and can effectively predict atherosclerosis. Carotid atherosclerosis is also associated with hypertension,diabetes,BMI,and lifestyle.