胆道闭锁DNA甲基化的研究进展

Research advances of DNA methylation in biliary atresia

胆道闭锁是新生儿期梗阻性黄疸的常见原因之一,其发病原因尚不明确,目前认为可能与遗传易感性、病毒感染、免疫损伤、毒素以及其他环境因素等有关。随着对胆道闭锁发病机制的不断研究,近年发现DNA甲基化异常可能与胆道闭锁发生相关,参与疾病发生发展中的炎症反应和胆管损害过程,下面对胆道闭锁DNA甲基化相关研究进展进行综述如下。

Biliary atresia (BA) is one of the common causes of neonatal obstructive jaundice and its pathogenesis has remained elusive. It is usually correlated with genetic susceptibility, viral infection, immune injury, toxin and other environmental factors. Further investigations have revealed that abnormal methylation of DNA is involved in inflammation and damage of bile duct. Its potential etiological role in BA is extensively reviewed.