药源性视力损害的文献分析

Literature analysis of drug-induced visual impairment

目的:探讨药源性视力损害的一般规律和特点,为临床安全用药提供参考。方法:检索中国知网、万方数据库、维普中文数据库中药物致视力损害的个案报道,对收集到的137篇文献进行统计和分析。结果:药源性视力损害共收集到159例,抗微生物药物58例,占36.48%;其次为麻醉药物19例,占11.95%;消化系统药物15例,占9.43%;内分泌系统药物13例,占8.18%,其他类药物54例,占33.96%。临床表现以双眼损害为主,中、轻度视力损害占69.81%,严重的视力损害占30.19%。结论:临床应重视药源性视力损害,加强用药监护并及时对症处理。

OBJECTIVE To investigate the general rules and characteristics of drug-induced visual impairment and provide references for clinical safe drug use. METHODS Case reports of drug-induced visual impairment in China Knowledge Network, Wanfang Database, and Wep Chinese database were searched, and 137 articles were collected for statistical analysis. RESULTS A total of 159 cases of drug-induced visual impairment were collected, 58 cases were antimicrobial drugs, accounting for 36.48%;19 cases were anesthetic drugs, accounting for 11.95%;15 cases were digestive drugs, accounting for 9.43%;13 cases were endocrine system drugs, accounting for 8.18%;54 cases were other drugs,accounting for 33.96%. The main clinical manifestations occurred in the eyes, including 69.81% moderate and mild visual impairment, and 30.19% of severe visual impairment. CONCLUSION Attentions should be paid to drug-induced visual impairment, to strengthen medication monitoring and timely supply symptomatic treatment.