小剂量抗精神病药物联合个体化康复治疗对长期住院精神分裂症患者生活能力的影响

Effect of low-dose antipsychotic drugs combined with individualized rehabilitation therapy on the living ability of patients with long-term hospitalized schizophrenia

探讨小剂量抗精神病药物联合个体化康复治疗对长期住院精神分裂症患者生活能力的影响。方法将住院时间超过24周的86例精神分裂症患者按随机数字表法分为研究组与对照组,各43例。两组均给予维持剂量的抗精神病药物治疗,研究组联合个体化康复治疗,观察3个月。比较治疗前后两组日常生活能力量表及护士用住院患者观察量表评分。结果治疗后研究组日常生活能力量表评分显著降低(P<0.01),且显著低于对照组(P<0.01)。对照组治疗前后比较差异无统计学意义(P>0.05)。治疗后研究组护士用住院患者观察量表社会能力、社会兴趣,个人整洁、迟缓因子评分显著低于治疗前(P<0.01),且显著低于对照组(P<0.01)。对照组治疗前后比较差异无统计学意义(P>0.05)。结论个体化康复治疗可以显著改善长期住院精神分裂症患者的日常生活能力,有利于社会功能的恢复,值得临床推广应用。

Objective To investigate the effect of low-dose antipsychotic drugs combined with individual- ized rehabilitation therapy on the living ability of patients with long-term hospitalized schizophrenia.Meth- ods 86 patients with schizophrenia who were hospitalized for more than 24 weeks were randomly divided into the study group and the control group,43 cases in each group.The two groups were all given mainte- nance dose of antipsychoties,the study group was combined with individualized rehabilitation treatment, patients were observed for 3 months.The ADL and NOSIE scores of the two groups before and after treatment were compared.Results After treatment,the ADL score in the study group was significantly declined (P<0.01),and was significantly lower than that of the control grgup (P<0.01).There was no significant difference in the control group before and after treatment (P>0.05).After treatment,the NOSIE factor scores (social ability,social interest,personal cleanliness,retardation)of the study group were significantly lower than those before treatment,and were significantly lower than those of the control group (P<0.01).There was no significant difference in the control group before and after treatment (P>0.05).Conclusion Individualized rehabilitation therapy can significantly improve the daily living ability of patients with long-term hospitalized schizophrenia,and is conducive to the recovery of social function,which is worthy of clinical application.