噻托溴铵联合沙美特罗替卡松治疗老年稳定期COPD疗效观察

Therapeutic effect of tiotropium combined with salmeterol fluticasone in elderly patients with stable COPD

目的 探讨噻托溴铵联合沙美特罗替卡松对老年稳定期慢性阻塞性肺疾病患者的临床疗效.方法 将125例老年稳定期慢性阻塞性肺病患者按随机数字表法分为两组.两组均给予噻托溴铵治疗,观察组联合沙美特罗替卡松治疗,观察6个月.比较治疗前后两组临床疗效、动脉血气指标、肺功能及不良反应发生率.结果 观察组总有效率显著高于对照组(P<0 .05).治疗后两组血酸碱度、血氧饱和度、氧分压均显升高(P<0 .01) ,二氧化碳分压均显著降低(P<0 .01) ,研究组较对照组变化更显著(P<0 .01).治疗后两组用力肺活量、第1 s用力呼气容积、第1 s用力呼气容积占预计值百分比均显著升高(P<0 .01) ,观察组较对照组升高更显著(P<0 .01).两组口干症发生率比较差异无统计学意义(P>0 .05).结论 噻托溴铵联合沙美特罗替卡松治疗老年稳定期COPD患者疗效显著,可显著改善动脉血气指标及肺功能,安全性较高.

Objective To investigate the clinical effect of tiotropium combined with salmeterol fluticasone in elderly patients with stable COPD.Methods 125 elderly patients with stable COPD were selected as the research objects and grouped according to the random number table.The two groups were all given tiotropium treatment ,and the observation group was plus salmeterol fluticasone on this basis ,all patients were observed for 6 months.The clinical efficacy ,arterial blood gas index ,lung function and adverse reaction rate were compared between the two groups before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).After treatment ,the blood acidity and alkalinity ,oxygen saturation and oxygen partial pressure were significantly increased (P<0.01) ,and the carbon dioxide partial pressure was significantly decreased (P<0.01). The observation group changed more significantly than the control group (P<0.01).After treatment ,the FVC ,FEV1 and FEV1% of the two groups were significantly increased (P<0.01) ,and the observation group changed more significantly than the control group (P<0.01).There was no significant difference in the incidence of xerostomia between the two groups (P>0.05).Conclusion Tiotropium combined with salmeterol fluticasone is effective in the treatment of elderly patients with stable COPD ,which can significantly improve arterial blood gas index and lung function ,and has higher safety.