5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物的合成及抑菌活性研究（英文）

Syntheses and Antifungal Activities of 5-Arylidene-2,3-diaryl-thiazolidin-4-one Derivatives

本文以多个2,3-二芳基噻唑-4-酮为底物,利用微波辅助的方法合成了18个5-芳亚甲基-2,3-二芳基噻唑-4-酮类衍生物,并测定了它们对7种植物病原菌的抑菌活性。它们的结构经熔点、1H NMR和MS确证。抑菌活性试验显示,化合物4g和4n表现出潜在的抑菌活性。

A series of 5-arylidene-2,3-diaryl-thiazolidin-4-one derivatives(4a^4r)were synthesized from 2,3-diphenyl-thiazolidin-4-one via microwave irradiation,and evaluated in vitro at the concentration of 100μg/mL against seven phytopathogenic fungi,namely Fusarium graminearum,Alternaria alternata,Fusarium oxysporium f.sp.vasinfectum,Pyricularia oryzae,Valsa mali,Alternaria solani and Alternaria brassicae.All the prepared compounds were characterized for structural confirmation by meltingNMR,and MS.The activity results indicated that4g and 4n exhibit potential antifungal activities against the phytopathogenic fungi.