孕晚期女性血清中25-(OH)D_3含量高低与产褥病的相关性分析

Analysis on the correlation between serum 25-(OH) D_3 level and puerperal disease in women during the third trimester of pregnancy

目的为了更好地指导临床对产褥病的诊治,分析孕晚期女性血清中25-(OH) D_3含量高低与产褥病的相关性。方法依据随机原则要求从2017年1-12月来该院分娩的正常孕晚期待产妇中抽取414例作为研究对象,所有产妇均接受血清25-(OH) D_3含量检测,同时根据待产妇血清25-(OH) D_3含量高低将其分为高维生素D组203例(≥50 nmol/L)和低维生素D组211例(<50 nmol/L),比较两组待产妇产褥感染率和产褥病发生率,并以此为依据探讨孕晚期女性血清中25-(OH) D_3含量高低与产褥病的相关性。结果入组孕晚期待产妇血清25-(OH) D_3平均含量为(70. 20±14. 48) nmol/L,且高维生素D组和低维生素D组待产妇的一般状况如年龄、分娩方式、既往分娩史等相似,组间比较差异无统计学意义(P>0. 05);其中高维生素D组产褥感染发生率和产褥病率分别为0. 99%和2. 46%,低维生素D组产褥感染和产褥病发生率分别为7. 11%和15. 17%,组间比较差异有统计学意义(P<0. 05)。结论孕妇血清25-(OH) D_3含量和其分娩时以及产后产褥病的发生及预防密切相关,临床低25-(OH) D_3含量产妇应及时预防产褥感染的发生,鼓励孕妇及时补充适量的维生素D。

Objective To better guide clinical diagnosis and treatment of puerperal diseases,analyze the correlation between serum25- (OH) D3 level and puerperal disease in women during the third trimester of pregnancy. Methods A total of 414 normal women during the third trimester of pregnancy were randomly selected from Longchang People ’ s Hospital from January to December in 2017,serum25- (OH) D3 levels were detected,all the women were divided into high vitamin D group (203 women,≥50 nmol/L) and low vitamin D group (211 women,<50 nmol/L) according to the levels of serum 25- (OH) D3. The incidence rates of puerperal infection and puerperal disease in the two groups were compared. The correlation between serum 25- (OH) D3 level and puerperal disease in women during the third trimester of pregnancy was analyzed. Results The average content of serum 25- (OH) D3 was (70. 20±14. 48) nmol/L. There was no statistically significant difference in the general situations (age,delivery mode,childbirth history) between high vitamin D group and low vitamin D group (P > 0. 05). The incidence rates of puerperal infection and puerperal disease in high vitamin D group were 0. 99% and2. 46%,respectively;the incidence rates of puerperal infection and puerperal disease in low vitamin D group were 7. 11% and 15. 17%,respectively;there were statistically significant differences between the two groups (P<0. 05). Conclusion The content of 25- (OH) D3 in pregnant women is closely related to the occurrence and prevention of puerperal disease during childbirth and after delivery. The women with low 25- (OH) D3 content should promptly prevent puerperal infection and encourage pregnant women to replenish right amount of vitamin D in time.