结核分枝杆菌耐药性检测专家共识

Expert consensus on detection of Mycobacterium tuberculosis drug resistance

耐药结核病尤其是耐多药结核病(MDR-TB)和广泛耐药结核病(XDR-TB)是目前临床亟待解决的难题之一,而对抗结核药物进行药物敏感性试验(DST)可为耐药结核病的诊断提供实验室依据。本专家共识简要地介绍了我国临床常用的结核分枝杆菌(MTB)DST方法(包括表型DST和分子DST);提出了MTB耐药性检测策略和正确判读检测结果的建议;指出目前DST检测技术和临床应用存在的问题,并对未来DST的发展前景进行了展望。

Drug-resistant tuberculosis (DR-TB) especially multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are one of the most difficult problems to be solved in clinical practice. Anti-tuberculous drug susceptibility tests (DST) provide experimental basis for the diagnosis of DR-TB. This expert consensus briefly introduces the common M.tuberculosis (MTB) DST methods (including phenotypic DST and molecular DST) used in clinic, proposes the strategies of MTB drug resistance detection and correct interpretation of the results, points out the problems of DST detection technology and clinical application, and prospects the development of DST in the future.