炎性因子及脂肪细胞因子与妊娠期糖尿病发病的关系

Study of inflammatory cytokines and adipokines relationship with gestational diabetes mellitus

目的:研究炎性因子(白介素-6(IL-6)、C反应蛋白(CRP)、脂肪细胞因子(瘦素、脂联素(ADP)与妊娠糖尿病(GDM)发病的关系及其在临床的应用价值。方法:选择2013年1月～2016年1月本院82例GDM患者设为GDM组,以64例正常孕妇为对照组,比较两组炎性因子IL-6、CRP以及瘦素、脂联素差异,研究GDM患者机体IL-6、CRP以及瘦素、脂联素与胰岛素抵抗指数(HOMA-IR)关系。结果:两组患者的FINS差异无统计学意义(P>0.05)。GDM组患者的IL-6、CRP、LEP、FPG、HOMA-IR均显著高于对照组(P<0.05),FDP显著低于对照组(P<0.05);GDM患者IL-6、CRP、LEP与HOMA-IR呈正相关(P<0.05),相关系数以IL-6(0.763)较高,FDP与HOMA-IR呈负相关(P<0.05)。结论:妊娠糖尿病的发病机制与胰岛素抵抗相关,炎性因素及脂肪细胞因子分泌失衡对胰岛素抵抗的形成起重要的推动作用。

Objective: To study the relationship between inflammatory cytokines(interleukin-6(IL-6),C-reactive protein(CRP),adipokines(leptin,adiponectin(ADP) and gestational diabetes mellitus(GDM) and the incidence of its clinical application value.Methods: From January 2013 to January 2016,82 patients with GDM were selected as GDM group and 64 normal pregnant women as control group.The differences of inflammatory factor IL-6,CRP,leptin and adiponectin between the two groups were compared.IL-6,CRP and leptin、adiponectin and insulin resistance index(HOMAIR) relationship were studied in GDM patients.Results: There was no significant difference in FINS between the two groups(P>0.05).The IL-6,CRP,LEP,FPG,HOMA-IR of the GDM groups was significantly higher than that of the control group(P<0.05),FDP was significantly lower than that in control group(P<0.05).The IL-6,CRP,LEP and HOMA-IR of the GDM groups were significantly lower than those of the control group(P<0.05).The correlation coefficient was higher in IL-6(0.763),and there was a negative correlation between FDP and HOMA-IR(P<0.05).Conclusion: Gestational diabetes pathogenesis associated with insulin resistance,inflammatory factors and cytokine secretion imbalance fat formation insulin resistance plays an important role in promoting.