术中甲状旁腺激素测定在甲状旁腺切除中应用

Application of intraoperative parathyroid hormone determination in parathyroidectomy

人体甲状旁腺合成和分泌甲状旁腺激素,甲状旁腺激素作用于骨骼和肾脏,从而调节血钙水平。甲状旁腺自身病变或其他疾病引起钙磷紊乱,导致甲状旁腺过度分泌甲状旁腺激素引起甲状旁腺功能亢进。继发性甲状旁腺功能亢进是慢性肾脏病患者的常见并发症之一,引起钙磷代谢失调、骨组织病变等一系列临床症状。对于难治性继发性甲状旁腺亢进,甲状旁腺切除术是主要的治疗手段。术中甲状旁腺激素测定是甲状旁腺手术过程中的一种功能性诊断工具,可以预测手术成功与否,并帮助术者决定是否需要进一步的探查,从而减少不必要的探查所导致的手术并发症。

In hunman body,parathyroid glands synthesize and secrete parathyroid hormone, which regulates serum salcium through bones and kidneys.Parathyroid autologous lesions or other diseases that cause serum calcium and phosphorus disorder,resulting in the excessive production of parathyroid hormone.Secondary hyperparathyroidism is one of the common complications of chronic kidney disease,causing a series of clinical symptoms such as calcium-phosphorus metabolism and bone tissue lesions.For refractory secondary hyperparathyroidism,parathyroidectomy is the main effective therapy.Intraoperative parathyroid hormone determination is a functional tool for predicting whether the parathyroideetomy is successful or not.Meanwhile,it can help the surgeon determine if further exploration is needed,which leads to the occurrence of complications.