期刊文献+

甲基化在肝纤维化过程中的作用及其机制的研究进展 被引量:5

Advances in research on role of methylation and its mechanism in liver fibrosis
原文传递
导出
摘要 目的总结DNA甲基化和组蛋白甲基化在肝纤维化中的作用机制。方法综述国内外有关探究肝纤维化过程中DNA甲基化和组蛋白甲基化的文献并进行分析总结。结果 DNA甲基化和组蛋白甲基化都是表观遗传学的重要组成部分,在肝纤维化过程中通过上调或下调某些基因表达,导致后续通路激活或失活,如PTEN、SEPT9、Smad7等在肝纤维化中呈高甲基化且表达降低,Spp1在肝纤维化中就呈低甲基化且表达增加。结论甲基化通过改变基因的表观遗传学从而影响基因的表达,通过对甲基化在肝脏疾病中的作用及机制进行系统而深入的研究可为肝脏疾病的治疗提供新的方向和靶向治疗的位点。 Objective To summarize mechanism of DNA methylation and histone methylation in liver fibrosis.Method The literatures on the DNA methylation and histone methylation during the liver fibrosis were reviewed and analyzed.Results The DNA methylation and histone methylation were the important components of epigenetics.The up-regulation or down-regulation of genes during the liver fibrosis leaded to the activation or inactivation of the subsequent pathways.For example,the PTEN,SEPT9,Smad7,etc.were hypermethylated and the expressions were decreased in the liver fibrosis.The Spp1 was hypomethylated and the expression was increased in the liver fibrosis.Conclusions Methylation affects expression of genes by altering epigenetics of genes.Systematic and in-depth study of role and mechanism of methylation in liver diseases provides a new direction and locations for some target treatments for liver disease.
作者 张恬莹 兰涛 魏玲玲 冯天航 黄孝伦 ZHANG Tianying;LAN Tao;WEI Lingling;FENG Tianghang;HUANG Xiaolun(Affiliated Hospital of University of Electronic Science and Technology of China .Sichuan Provincial People's Hospital,Chengdu 610072,P.R.China;Zunyi Medical University,Zunyi,Guizhou 563003,P.R.China)
出处 《中国普外基础与临床杂志》 CAS 2019年第2期229-235,共7页 Chinese Journal of Bases and Clinics In General Surgery
基金 国家科技部重点基础研究发展计划(973计划)项目(项目编号:2015CB964703) 四川省科技计划项目(项目编号:2016JY0020)
关键词 DNA甲基化 组蛋白甲基化 肝纤维化 DNA methylation histone methylation liver fibrosis
  • 相关文献

参考文献1

二级参考文献95

  • 1Sheng, Qin-Song,Lang, Ren,He, Qiang,Yang, Yong-Jiu,Zhao, De-Fang,Chen, Da-Zhi.Indocyanine green clearance test and model for end-stage liver disease score of patients with liver cirrhosis[J].Hepatobiliary & Pancreatic Diseases International,2009,8(1):46-49. 被引量:37
  • 2Virginia Hernandez-Gea,Fanny Turon,Annalisa Berzigotti,Augusto Villanueva.Management of small hepatocellular carcinoma in cirrhosis:Focus on portal hypertension[J].World Journal of Gastroenterology,2013,19(8):1193-1199. 被引量:20
  • 3■ukasz Liszka,Ewa Zielińska-Paj■k,Jacek Paj■k,Dariusz Goka,Jacek Starzewski,Zbigniew Lorenc.Usefulness of two independent hist classifications of tumor regression iUsefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy[J].World Journal of Gastroenterology,2007,13(4):515-524. 被引量:2
  • 4Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter Kremers,Terry M. Therneau,Catherine L. Kosberg,Gennaro D’Amico,E.Rolland Dickson,W.Ray Kim.A model to predict survival in patients with end-stage liver disease[J]. Hepatology . 2001 (2)
  • 5Chi-Leung Liu,Sheung-Tat Fan,Chung-Mau Lo,Yik Wong,Irene Oi-Lin Ng,Chi-Ming Lam,Ronnie Tung-Ping Poon,John Wong.Abdominal Drainage After Hepatic Resection Is Contraindicated in Patients With Chronic Liver Diseases[J]. Annals of Surgery . 2004 (2)
  • 6Roberto de Franchis.Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension[J].Journal of Hepatology.2010(4)
  • 7John T. Mullen,Dario Ribero,Srinevas K. Reddy,Matteo Donadon,Daria Zorzi,Shiva Gautam,Eddie K. Abdalla,Steven A. Curley,Lorenzo Capussotti,Bryan M. Clary,Jean-Nicolas Vauthey.Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy[J].Journal of the American College of Surgeons.2007(5)
  • 8Wen-Tsan Chang,Wei-Yu Kao,Gar-Yang Chau,Chien-Wei Su,Hao-Jan Lei,Jaw-Ching Wu,Cheng-Yuan Hsia,Wing-Yiu Lui,Kuang-Liang King,Shou-Dong Lee.Hepatic resection can provide long-term survival of patients with non–early-stage hepatocellular carcinoma: Extending the Indication for resection?[J].Surgery.2012(5)
  • 9Yoshito Tomimaru,Hidetoshi Eguchi,Shigeru Marubashi,Hiroshi Wada,Shogo Kobayashi,Masahiro Tanemura,Koji Umeshita,Yuichiro Doki,Masaki Mori,Hiroaki Nagano.Equivalent Outcomes After Anatomical and Non-anatomical Resection of Small Hepatocellular Carcinoma in Patients with Preserved Liver Function[J].Digestive Diseases and Sciences.2012(7)
  • 10Divya Dahiya,Ting-Jung Wu,Chen-Fang Lee,Kun-Ming Chan,Wei-Chen Lee,Miin-Fun Chen.Minor versus major hepatic resection for small hepatocellular carcinoma (HCC) in cirrhotic patients: A 20-year experience[J].Surgery.2010(5)

共引文献24

同被引文献34

引证文献5

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部