个性化添加母乳强化剂对母乳喂养早产儿生长发育的影响

Effect of individualized breast milk fortifier on the growth and development of breastfed premature infants

目的探讨个性化添加母乳强化剂在母乳喂养早产儿中的应用效果,为早产儿的喂养提供依据。方法选择2016年1月-2017年12月在天津市滨海新区塘沽妇产医院新生儿科住院并定期在天津市滨海新区妇女儿童保健和计划生育服务中心监测生长发育情况的120例早产儿,随机分为两组(每组60例),对照组采取标准母乳强化剂喂养,观察组在母乳喂养中根据早产儿蛋白质摄入量实施个性化添加母乳强化剂,比较两组的体重、身长、头围和喂养并发症的发生情况。结果喂养后1个月、2个月、3个月,两组早产儿的体重、身长、头围均明显增高,时间效应差异有统计学意义(P<0.05);与对照组比,观察组的早产儿的体重、身长、头围均明显增高,干预效应差异有统计学意义(P<0.05)。观察组的喂养不耐受发生率、坏死性小肠结肠炎发生率均低于对照组(χ2=4.821、5.217,P<0.05)。结论相比于标准母乳强化剂喂养,在母乳喂养早产儿中实施个性化添加母乳强化剂喂养可更好地促进早产儿体格生长,且该母乳强化喂养方式的安全性更高,可减少喂养并发症发生。

Objective To investigate the effect of individualized breast milk fortifier in breastfed premature infants,in order to provide reference for the appropriate feeding of premature infants. Methods A total of 120 premature infants were selected from January 2016 to December 2017 in Tanggu Obstetrics and Gynecology Hospital of Binhai District,Tianjin,who were hospitalized in pediatrics department and monitored their growth and development in Tianjin Binhai New Area Women and Children Health and Family Planning Service Center regularly.The participants were randomly divided into two groups,with 60 cases in each group.The control group was fed with standard breast milk fortifier,while the observation group was fed with individualized breast milk fortifier according to the protein intake of premature infants.The weight,length and head circumference,and feeding complications of the two groups were compared. Results The body weight,body length and head circumference of premature infants in two groups were higher in 1 month,2 months and 3 months after feeding,with significant time influence(P<0.05).And these indicators in the observation group were higher than those in the control group,with significant intervention influence(P<0.05).The incidence rates of feeding intolerance and necrotizing enterocolitis in the observation group were significantly lower than those in the control group(χ^2=4.821、5.217,P<0.05). Conclusions Compared with the standard breast-feeding agent,individualized breast milk fortifying agent can promote the physical growth of premature infants better.And the individualized breast milk fortifying is safer than standard breastfeeding fortifier,because it can reduce the incidence of feeding complications.