三磷酸鸟苷环化水解酶1研究进展

Progress on study of guanosine triphosphate cyclohydrolase 1

三磷酸鸟苷环化水解酶1(GTPCH1)是由GCH1基因编码合成的蛋白产物,在生理条件下,催化底物GTP生成具有生物活性的四氢生物蝶呤(BH4)。BH4是芳香族氨基酸羟化酶的辅酶、一氧化氮合酶的辅因子,参与各种激素和神经递质的合成,并在体内一系列病理生理过程中起重要作用。研究表明,GTPCH1在神经病理性疼痛、多巴反应性肌张力障碍、肿瘤、心血管等疾病的发病机制中起重要作用。本文就GTPCH1在上述疾病发病机制中的作用研究进展进行阐述。

Guanosine triphosphate cyclohydrolase 1 (GTPCH1)is a protein encoded by the GCH1 gene,which catalyze GTP to tetrahydrofolinine (BH4)under physiological condition.BH4 is a coenzyme of aromatic amino acid hydroxylase and a cofactor of nitric oxide synthases.BH4 involves in the synthesis of various hormones and neurotransmitters and plays an important role in a series of pathophysiological processes in vivo.Recent studies showed that GTPCH1 is involved in the pathogenesis of neuropathic pain,doparesponsive dystonia,cancer and cardiovascular diseases.In this review,we will discuss the role of GTPCH1 in those diseases mentioned above.