尘肺病患者肺功能与血气分析相关性研究

Correlation between pulmonary function and blood gas in patients with pneumoconiosis

目的了解淄博市尘肺病患者肺功能与血气分析的基本情况,探讨两者之间的相关性。方法对141例尘肺病患者进行肺功能和血气分析检查,分析两者同尘肺病期别、工龄、年龄的关系,以及肺功能受损程度与血气分析的关系。结果随着尘肺病期别的提高,肺功能第1秒用力呼气量(FEV1)、1秒率(FEV1%)、呼气峰流速值(PEF)、一氧化碳弥散量(DLCO)和血气分析动脉血氧分压(PaO_2)各指标有下降趋势(r=-0.395、-0.373、-0.398、-0.373、-0.203,均P<0.05)。随着年龄增长,肺功能FEV1、PEF和血气分析PaO_2各指标呈下降趋势(r=-0.208、-0.194、-0.219,均P<0.05),肺泡与动脉毛细血和血氧分压差[P(A-a)O_2]指标呈上升趋势(r=0.186,P<0.05)。肺功能和血气分析指标与工龄无关。血气分析指标PaO_2与肺功能指标FEV1、FEV1%、PEF、DLCO呈正相关(r=0.312、0.217、0.200、0.232,均P<0.05),P(A-a)O_2与肺功能指标FEV1、FEV1%、PEF、DLCO呈负相关(r=-0.297、-0.167、-0.179、-0.246,均P<0.05)。肺功能损伤程度与血气分析指标PaO_2呈负相关(r=-0.360,P<0.01)。结论通过对尘肺病患者肺功能和血气分析相关性的研究,本研究认为尘肺病期别及年龄均可影响肺功能和血气分析,与患者的接尘工龄无关。尘肺病患者肺功能的损伤与血气分析的情况一致。

[Objective]To investigate the relationship between pulmonary function and blood gas in patients with pneumoconiosis in Zibo City.[Methods ]The pulmonary function and blood gas test were performed in 141 patients with pneumoconiosis,to analyze the relationship between them and the stage of pneumoconiosis,length of service,age.The degree of lung function damage and blood gas analysis was analyzed.[Results]As the stage of pneumoconiosis increased,the pulmonary function indexes of forced expiratory volume in the first second(FEV1),the ratio of FEV1(FEV1%),peak expiratory flow(PEF),carbon monoxide diffusion capacity(DLCO)and blood gas analysis index of arterial partial pressure of oxygen(PaO2)showed a tendency to decrease(r=-0.395,-0.373,-0.398,-0.373,-0.203,all P<0.05).With the increase of age,the pulmonary function indexes of FEV1 and PEF blood gas analysis index of PaO2 showed a decreasing trend(r=-0.208,-0.194,-0.219,all P<0.05),and the alveolar and arterial capillary blood and oxygen partial pressure difference[P(A-a)O2]showed an increasing trend(r=0.186,P<0.05).The indexes of pulmonary function and blood gas analysis were not related to length of service.The blood gas analysis index of PaO2 was positively correlated with the pulmonary function indexes of FEV1,FEV1%,PEF and DLCO(r=0.312,0.217,0.200,0.232,all P <0.05),while P(A-a)O2 was negatively correlated with the pulmonary function indexes of FEV1,FEV1%,PEF and DLCO(r=-0.297,-0.167,-0.179,-0.246,all P<0.05).There was a negative correlation between the degree of lung function injury and the blood gas analysis index of PaO2(r=-0.360,P<0.01).[Conclusion]Through the study of the correlation between lung function and blood gas analysis in patients with pneumoconiosis,it is considered that the stage and age of pneumoconiosis can affect the lung function and blood gas analysis,and is not related to the length of exposure to dust.Lung function damage in pneumoconiosis patients is consistent with blood gas analysis.