鼻咽内超声实时引导经鼻咽针吸活检术在诊断黏膜下型鼻咽癌中的初步应用

Preliminary application of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration in the diagnosis of submucosal nasopharyngeal carcinoma

目的探讨鼻咽内超声实时引导经鼻咽针吸活检术(endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration,ENUS-TNNA)诊断黏膜下型鼻咽癌的可行性,安全性及临床应用价值。方法回顾性分析2013年12月至2018年1月四川省肿瘤医院内镜中心采用ENUS-TNNA技术诊断的9例黏膜下型鼻咽癌患者的临床资料,分析其安全性及可行性。结果9例患者均为男性,平均年龄(49.2±10.9)岁。全组病例均一次性穿刺成功,获得了足够的组织标本,穿刺过程术中、术后未发生大出血或持续性渗血。9例患者术后病理结果证实鼻咽未分化非角化性癌5例,鼻咽低分化非角化性癌4例。结论ENUS-TNNA在技术上安全可行,是诊断黏膜下型NPC的有效方法,具有一定的临床价值。

Objective To evaluate the feasibility, safety and clinical value of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration (ENUS-TNNA) in the diagnosis of submucosal nasopharyngeal carcinoma.Methods Clinical data of 9 patients from Sichuan Cancer Hospital with submucosal nasopharyngeal carcinoma undergoing ENUS-TNNA between December 2013 and January 2018 were retrospectively analyzed. The feasibility and safety were analyed. All 9 patients were all males with a mean age of (49.2±10.9) years.Results Needle puncture biopsies were successfully performed in all cases, and sufficient tissue sample for histopathological examination was obtained from each of the 9 patients. No major bleeding or persistent bleeding occurred during and after puncture procedures. There were 5 patients with undifferentiated nonkeratinizing carcinoma and 4 patients poorly differentiated carcinoma.Conclusion ENUS-TNNA is a safe, feasible and effective technique to provide a diagnosis of submucosal growth type of nasopharyngeal neoplasms, which has some clinical value.