肝切除术治疗小混合型肝癌的结果分析

Outcome of liver resection for small combined hepatocellular-cholangiocarcinoma

目的探讨肝切除术治疗小混合型肝癌的临床疗效。方法回顾性分析华中科技大学同济医学院附属普爱医院2009年6月至2017年6月肝切除治疗的13例直径≤5cm的混合型肝癌病人和256例直径≤5cm肝细胞癌病人的临床病理资料和预后。结果混合型肝癌病人和肝细胞癌病人术后1年、3年、5年无瘤生存率分别为84%、50%、37%和82%、61%、45%(P=0.406);1年、3年、5年总体生存率分别为92%、73%、58%和94%、78%、65%(P=0.509),两组病人无瘤生存率和总体生存率差异无统计学意义。结论肝切除术治疗小混合型肝癌病人可获得长期预后。

Objective To evaluate long-term outcomes of liver resection for patients with small combined hepatocellular-cholangiocarcinoma(cHCC-CC).Methods A total of 13 patients diagnosed as cHCC-CC≤5 cm undergoing liver resection at our institution from 2009 to 2017 were retrospectively analyzed.The clinicopathological features and outcomes were compared between those patients with cHCC-CC and 256 patients with HCC ≤5 cm,who had undergone a hepatic resection during the same period.Results All of them were given liver resection and followed up.The 1-,3-and 5-year recurrence-free survival(RFS)rate of patients with cHCC-CC and those with HCC was 84%,50% and37%,and 82%,61% and 45%respectively(P=0.406>0.05).The 1-,3-and 5-year overall survival(OS)rate of patients with cHCC-CC and those with HCC was 92%,73% and 58%,and 94%,78%and 65%respectively(P=0.509>0.05).There was no significant difference in RFS and OS rate between two groups.Conclusions Liver resection for patients with cHCC-CC ≤5 cm,as well as HCC,could have an acceptable long-term outcome.