枸橼酸咖啡因联合经鼻持续气道正压通气对极低出生体质量儿呼吸管理的临床效果

Clinical effect of caffeine citrate combined with nasal continuous positive airway pressure ventilation on respiratory management in very low birth mass infants

目的研究枸橼酸咖啡因联合经鼻持续气道正压通气对极低出生体质量儿呼吸管理能够取得的作用效果。方法选取50例本院收治的极低出生体质量儿(VLBW)研究对象,两组胎儿在入院后均采取措施治疗原有病症,进行给予补给液,维持电解质等综合治疗措施的基础上,分为试验组和对照组。试验组采用枸橼酸咖啡因联合经鼻持续气道正压通气的方式对婴儿进行呼吸治疗,对照组单独采用经鼻持续气道正压通气的治疗方式。比较两组的治疗效果。结果试验组的治疗有效率显著高于对照组,不良反应发生率和呼吸暂停发生数均低于对照组,且呼吸暂停消失时间明显少于对照组。数据差异有统计学意义(P <0.05)。结论应用枸橼酸咖啡因联合鼻持续正压通气对于VLBW的呼吸管理具有很好的效果,能够减少治疗时间,提高治疗有效率,减少呼吸暂停和不良反应的发生,提高VLBW的生存质量。

Objective To study the effect of caffeine citrate combined with nasal continuous positive airway pressure on respiratory management of very low birth weight infants. Methods 50 cases of very low birth weight infants(VLBW)admitted to our hospital were randomly divided into the experimental group and the control group. The experimental group was treated with caffeine citrate combined with nasal continuous positive airway pressure ventilation for infants, and the control group was treated by nasal continuous positive airway pressure ventilation alone. The therapeutic effects of the two groups were compared. Results The effective rate of treatment in the experimental group was significantly higher than that of the control group. The incidence of adverse reactions and the number of apnea were lower than that of the control group, and the time of apnea was less than that of the control group. The difference of data is statistically significant(P < 0.05). Conclusion The application of caffeine citrate combined with nasal continuous positive pressure ventilation has a good effect on the respiratory management of VLBW. It can reduce the time of treatment, improve the efficiency of treatment, reduce the occurrence of apnea and adverse reactions, and improve the quality of life of VLBW.