脂肪组织和脂肪因子与子宫内膜异位症关系的研究进展

Research progress on the relationship between adipose tissue and adipokines and endometriosis

脂肪组织不仅具有能量储存、保暖等功能,作为人体最大的内分泌器官,还可以通过分泌瘦素、脂联素等多种脂肪因子、细胞间黏附分子-1(ICAM-1)等黏附分子及血管内皮生长因子(VEGF)等血管生成因子参与人体免疫、炎症、脂类代谢、血管生成等。子宫内膜异位症(EMS)患者体质量指数(BMI)、血清及腹腔中瘦素、抵抗素、脂联素等多种脂肪因子浓度、黏附分子及血管生成因子浓度与非EMS患者间存在明显差异,这可能是脂肪组织及脂肪因子通过促炎、促进血管生成、产生胰岛素抵抗(IR)等作用促进异位子宫内膜的黏附、侵袭以及血管形成。现就脂肪组织及其分泌的脂肪因子、黏附分子及血管生成因子在EMS发生、发展中的作用进行综述。

Adipose tissue not only has the function of energy storage and heat preservation, as the largest endocrine organ in human body, can also be involved in the human body immunity, inflammation, lipid metabolism, angiogenesis and so on, through the secretion of leptin, adiponectin and other adipokines, adhesion molecule such as intercellular cell adhesion molecule-1 (ICAM-1), and angiogenic factors such as vascular endothelial growth factor (VEGF). Body mass index (BMI), serum or intraperitoneal leptin, resistin, adiponectin concentrations, such as adhesion molecules and angiogenesis factors between endometriosis (EMS) patients and women without EMS were significant differences. It may be that adipose tissue and adipose factors promote adhesion, invasion and angiogenesis of ectopic endometrium by promoting inflammation, promoting angiogenesis, and producing insulin resistance. The role of adipose tissue and its secreted adipokines, adhesion molecules and angiogenesis factors in the development of EMS are reviewed.