红葱鳞茎中1个新的萘酚类化合物

A new naphthalene derivative from bulbs of Eleutherine americana

采用硅胶柱色谱及半制备高效液相色谱对红葱鳞茎石油醚部位进行化学成分研究,并通过MS,UV,IR,NMR等波谱技术鉴定其结构。从红葱鳞茎石油醚部位分离得到4个化合物,分别鉴定为红葱酚B(1)、4,8-二羟基-3-甲氧基-1-甲基蒽醌-2-羧酸甲酯(2),8-羟基-3,4-二甲氧基-1-甲基蒽醌-2-羧酸甲酯(3)和异红葱乙素(4),其中1为新化合物。10μmol·L-1浓度下化合物1和2的舒张血管作用较强,达到了82.5%和85.3%,与阳性药丹参酮ⅡA(86.3%)基本一致。

A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques,such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date( MS,UV,IR,NMR),which were identified as eleutherol B( 1),4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester( 2),8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester( 3),and isoeleutherine( 4). Compound 1 is a new compound. The diastolic blood vessels activity of compound 1 and 2 were potent,reaching 82. 5% and 85. 3% at the concentration of 10 μmol·L-1,which were basically the same as that of the positive drug tanshinoneⅡA.