天然倍半萜类化合物抗炎作用机制的研究进展

Research progress on anti-inflammatory mechanism of natural sesquiterpenoids

倍半萜是自然界中分布较广的一类化合物,具有抗炎、抗肿瘤、免疫调节等广泛的生物活性。该文对倍半萜化合物抗炎作用机制进行了综述,其作用机制主要是通过抑制NF-κB,MAPKs和STAT等信号通路相关因子的活化,下调TNF-α,PGE2,NO,IL-1,IL-6,IL-8等炎性因子的蛋白表达,进而减少炎症因子的产生与释放而发挥作用。该文旨在为相关研究提供借鉴和参考。

Sesquiterpenoid is a kind of compound widely distributed in nature,which has a wide range of biological activities,such as anti-inflammatory,anti-tumor and immunomodulatory activities. This paper would review the anti-inflammatory mechanism of sesquiterpenoid. The mechanism is mainly by inhibiting the activation of nuclear factor(NF-κB),mitogen-activated protein kinase(MAPKs) and signal transducers and activators of transcription(STAT) signaling pathways and down-regulating the inflammatory gene expression including tumor necrosis factor-α(TNF-α),prostaglandin E2(PGE2),nitric oxide(NO),interleukin-1(IL-1),IL-6,IL-8 and other inflammatory factors. Thereby,the production and release of inflammatory cytokines are reduced to exert anti-inflammatory effect. This review is intended to provide reference for related research.