摘要
松萝酸及类似物为地衣类植物的特征成分之一,是一类重要的有机酸类分子,具有抗病毒、抗菌、抗癌、抗炎镇痛、麻醉等药理活性,在医药等领域应用广泛,但也能引起皮炎甚至肝功能损坏。学者们通过化学分离类似物、有机合成衍生物或结构修饰等多种努力以寻找毒副作用更小或活性更好的类似物。该文对松萝酸及类似物的资源分布、分离鉴定、结构特征、合成修饰、药理活性及相关毒性研究进行系统归纳整理,以期为松萝酸及类似物的开发利用提供参考。
Usnic acid and its derivatives, a group of organic molecules with great importance, are characteristic to lichens, possessing pharmacological activities such as anti-virus, anti-bacteria, anti-humor, anti-inflammatory, analgesic, and anaesthetic effects. Many of them have been widely used as medicine, but also bring side effects such as dermatitis and liver damages. In the past decades, great efforts by isolation, organic synthesis, and structure modification methods were put on discovery of UA derivatives with higher biological activities or less side effects. This paper describes herein the most progress on natural sources, isolation and structure elucidation, structural characteristics, synthesis and modification results, pharmacological activities and toxicities of UA and its derivatives, hopefully to provide valuable reference for further research.
作者
沙娜·吾肯
焦顺刚
杨鑫瑶
高小力
曲昌海
张倩
刘春生
屠鹏飞
柴兴云
WUKEN Sha-na;JIAO Shun-gang;YANG Xin-yao;GAO Xiao-li;QU Chang-hal;ZHANG Qian;LIU Chun-sheng;TU Peng-fei;CHAI Xing-yun(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第19期3811-3821,共11页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81774001,81473426)
关键词
松萝酸
松萝酸类似物
地衣
结构修饰
化学成分
药理活性
usnic acid
usnic analogues
lichens
structural modification
chemical composition
pharmacological activity