长期服用人参提取物对大鼠肠道菌群结构的影响

Effect of long-term intake of ginseng extracts on gut microbiota in rats

人参作为中国的传统中药,有着广泛的药用和保健价值,目前人参作为药用食品的营养价值一直是研究热点。肠道菌群在机体中发挥的重要作用得到众多研究者的肯定,该研究利用MiSeq测序平台对长期服用人参提取物的大鼠盲肠内容物样本进行宏基因测序,之后通过对肠道菌群数据结果分析,探究长期服用人参提取物对大鼠肠道菌群结构产生的影响。结果表明,经过长期服用人参提取物,大鼠肠道菌群中的益生菌属如Bifidobacterium,Lactobacillus,Allobaculum,Clostridium等发生显著上调,而致病菌属如Butyricimonas,Parabacteroides,Alistipes,Helicobacter等发生显著下调,证明长期服用人参提取物有助于促进益生菌生长而抑制致病菌生长,该研究为长期服用人参提取对大鼠肠道菌群结构的影响提供了重要依据。

As a traditional Chinese medicine in China, ginseng has a wide range of medicinal and health value. At present, the nutritional value of ginseng as a medicinal food has been a hotspot in studies. Intestinal flora plays an important role in the organism, which has been confirmed by many researchers. In order to find out the effect of long-term intake of ginseng extracts on the gut microbiota structure of rats, MiSeq sequencing platform was applied in macro gene sequencing of cecal contents in the long-term use of ginseng extracts modelin rats. According to the findings, after long-term administration with ginseng extracts, probiotics such as Bifidobacterium, Lactobacillus, Allobaculum and Clostridium, in the intestinal flora of rats were significantly increased, suggesting that long-term intake of ginseng extracts could facilitate the growth of probiotics. Meanwhile, some pathogenic bacteria, such as Butyricimonas, Parabacteroides, Alistipes, Helicobacter, were significantly down-regulated, indicating that long-term intake of ginseng extracts may have a positive effect in inhibiting the colonization of pathogenic bacteria. In conclusion, this study provided an important basis for the research on the effect of long-term use of ginseng extracts on the intestinal flora of rats.