BISAP评分联合TG、MAP1-LC3对急性胰腺炎预后的预测价值

Predictive value of BISAP score combined with TG and MAP1-LC3 in the prognosis of acute pancreatitis

[目的]:探讨急性胰腺炎(AP)严重程度床边指数(BISAP)评分联合甘油三酯(TG)、微管相关蛋白1轻链3(MAP1-LC3)对急性胰腺炎预后的评估价值。[方法]选择2014年3月～2018年6月我院收治的154例AP患者为研究对象,根据病情严重程度分为轻症AP(MAP)组和重症AP(SAP)组,2组患者分别为82例和72例,另选取同期来我院进行检查的56例健康人作为对照组。对MAP和SAP组患者BISAP评分进行比较,采用ELISA法检测3组血清TG和MAP1-LC3水平并进行比较。[结果]SAP组BISAP评分显著高于MAP组,差异有统计学意义(P<0.05);不同预后结局中,死亡患者BISAP评分显著高于多器官功能障碍综合征(MODS)和胰腺坏死患者;SAP组血清TG和MAP1-LC3水平显著高于MAP组和对照组,差异有统计学意义(P<0.05);Person相关性分析显示BISAP评分与血清TG、MAP1-LC3水平呈正相关;BISAP评分联合TG和MAP1-LC3预测死亡患者的准确度显著高于单独BISAP评分预测,差异有统计学意义(P<0.05)。[结论]BISAP评分、TG和MAP1-LC3是评估AP预后的重要指标,BISAP评分联合血清TG和MAP1-LC3能够有效预测AP预后,准确度高,具有重要的预后预测价值,值得在临床进一步应用。

[Objective]To investigate the value of acute pancreatitis(AP)severity bedside index(BISAP)score combined with triglyceride(TG)and microtubule-associated protein 1 light chain 3(MAP1-LC3)in evaluating the prognosis of acute pancreatitis.[Methods]A total of 154 AP patients admitted to our hospital from March 2014 to June 2018 were enrolled.The patients were divided into mild AP(MAP)group and severe AP(SAP)group according to the severity of the disease,with 82 cases and 72 cases in each group.Another 56 healthy people who were examined in our hospital were selected as the control group.The BISAP scores of MAP and SAP patients were compared.The levels of serum TG and MAP1-LC3 were detected by ELISA and compared.[Results]The BISAP score of SAP group was significantly higher than that of MAP group(P<0.05).Among different prognosis outcomes,the BISAP score of death patients was significantly higher than that of patients with multiple organ dysfunction syndrome(MODS)and pancreatic necrosis.The levels of serum TG and MAP1-LC3 in the SAP group were significantly higher than those of MAP group and control group(P<0.05).Person correlation analysis showed that BISAP score was positively correlated with serum TG and MAP1-LC3 levels.The accuracy of BISAP score combined with TG and MAP1-LC3 for predicting death was significantly higher than that of BISAP score alone,and the difference was statistically significant(P<0.05).[Conclusion]BISAP score,TG and MAP1-LC3 are important indicators for evaluating the prognosis of AP.Combined with serum TG and MAP1-LC3,BISAP score can effectively predict AP prognosis with high accuracy and important prognostic value.It is worth further application in clinical.