基于“微生物-脑-肠轴”观察理肠汤对脾虚湿困型溃疡性结肠炎患者的作用

Observation of the effect of Lichang decoction on spleen-deficiency and dampnesstype ulcerative colitis patients based on “microbial-brain-intestinal axis”

[目的]探讨理肠汤通过"微生物-脑-肠轴"对溃疡性结肠炎(UC)患者的作用。[方法 ]治疗组以理肠汤联合柳氮胺吡啶肠溶片,单纯服用柳氮磺胺吡啶肠溶片为对照组,干预脾虚湿困型UC患者,对比2组患者肠道微生态、血清脑肠肽、短链脂肪酸的改善情况。并对比患者结肠镜下黏膜评分的改善程度。[结果]治疗组在双歧杆菌、乳杆菌、酵母菌的改善方面明显优于对照组(P<0.05);对SP、SS、乙酸、丙酸的调节优于对照组(P<0.05);对患者肠镜下黏膜变脆易损及黏膜损害改善也明显优于对照组(P<0.05)。且在治疗过程中未发现临床不良事件的发生。[结论]理肠汤对脾虚湿困型UC患者安全有效。

[Objective]To investigate the effect of Lichang decoction on patients with ulcerative colitis(UC)through " microbial-brain-gut axis".[Methods]The treatment group was treated with Lichang decoction combined with sulfasalazine enteric-coated tablets,and the single administration of salazylaminopyridine enterolysis tablets was used as the control group to intervene in wet-trapped UC patients with spleen deficiency,the improvement of intestinal microecology,serum brain-gut peptide and short-chain fatty acid in the two groups were compared,and the degree of improvement of the colonic mucosal score in patients were compared.[Results]The treatment group was significantly better than the control group in the improvement of Bifidobacterium,Lactobacillus and Yeast(P<0.05).The regulation of SP,SS,acetic acid and propionic acid was better than that of the control group(P<0.05).The mucosal embrittlement and mucosal damage of the patients under the colonoscopy was also significantly better than the control group(P<0.05).No clinical adverse events were found during the treatment.[Conclusion]Lichang decoction is safe and effective for patients for spleen-deficiency and dampness-type UC patients.