肾移植患儿生长发育障碍

Growth retardation after paediatric renal transplantation

慢性肾脏疾病的儿童常伴生长发育障碍,对儿童身心发育造成严重影响,肾脏移植是治疗儿童终末期肾病的最有效替代方法,与维持透析相比,儿童肾移植后不仅可以获得长期存活,其生长发育和认知能力也得到显著改善,从而最大程度恢复患儿正常的学习和生活。肾移植后患儿生长发育情况获得不同程度的改善,主要与移植年龄、移植物功能、糖皮质激素和生长激素有关。因此,生长发育的好坏对于肾移植患儿的生理和心理成长都至关重要。

Growth failure is frequently observed in children with end-stage renal disease( ESRD),and a short stature possibly affects a child’s psychological and social development.Kidney transplantation is currently the best treatment option for children with ESRD. Moreover,as the duration of dialysis progresses,the potential for renal bone disease and epiphyseal closure increases.Renal transplantation can obviously improve children’s growth and quality of life.Consequently,the growth after RTx has notably improved which is related with age,the function of grafts and the use of glucocorticoid and growth hormone.This review is focused on recent studies about growth after paediatric renal transplantation.