肾移植术后人细小病毒B19感染

Human parvovirus B19 infection after renal transplantation

青年男性,因慢性肾脏病5D期行右侧同种异体肾移植术,术后2个月血红蛋白逐渐下降,反复输血、注射红细胞生成素及调整免疫抑制剂后,仍进行性贫血,骨髓示红系增生减低,血清核酸学检查示人细小病毒(HPV) B19 DNA高滴度复制。最终诊断为HPV B19感染(纯红细胞再生障碍性贫血),予丙种球蛋白治疗,患者血清HPV B19 DNA复制明显下降,血红蛋白升至正常。因此,肾移植术后患者出现不明原因的血红蛋白下降,应注意排除HPV B19的感染。

A 32-year-old male was characterized by persistent anemia after renal transplantation,and the bone marrow examination suggested erythroid development with an absence of late normoblasts. After nucleic acid detection,the final diagnosis was pure red cell aplasia after the human parvovirus B19( HPV B19) infection.After human gamma-globulin therapy,peripheral blood cell analysis showed HPV B19 DNA replication decreased significantly,and recovery of hemoglobin,suggesting that anemia was corrected. Therefore,patients after renal transplantation with persistent anemia of unknown origin,we need to alert HPV B19 infection.