肠道杯状细胞在肠道免疫调控中作用的研究进展

Progress in the role of intestinal goblet cells in intestinal immune regulation

杯状细胞(GC)是人和哺乳动物的一种单细胞腺,分布于人体呼吸道、消化道、生殖道等部位的上皮中。肠道内的黏蛋白2(MUC2)主要由GC分泌,黏蛋白和水、无机盐等在肠道黏膜上皮表面形成黏液屏障,在抵御外源细菌和肠道固有微生物侵袭、维持肠黏膜动态平衡、调控微生物-宿主免疫应答中起重要作用。更重要的是GC及其分泌黏蛋白的缺陷与肠道多种疾病密切相关。我们总结了GC的结构和功能及其在肠道免疫调控中的研究进展。

Goblet cells( GCs) are single-cell glands of humans and mammals,which are distributed in the epithelia of the respiratory tract,digestive tract,reproductive tract and so on. The mucin 2( MUC2) in the intestine is mainly secreted byGCs. Mucin,water and inorganic salts form a mucous barrier on the surface of the intestinal mucosa,which plays animportant role in resisting the invasion of foreign bacteria and intestinal microbes,maintaining the dynamic balance of intestinalmucosa and regulating the microbial-host immune response. More importantly,the defects of GCs and its secreted mucin areclosely related to various diseases of the intestine. We summarized the structure and function of GCs and its researchprogress in intestinal immune regulation.