帕金森伴抑郁的中医证候及神经可塑性机制研究进展

Study Progress of TCM Syndrome and Neuroplasticity Mechanism of Parkinson's Disease with Depression

帕金森伴抑郁属于中医"颤证"与"郁证"合病范畴,其证候特征及证型分布与单纯颤证、郁证有所不同,其神经可塑性机制涉及多巴胺、五羟色胺、去甲肾上腺素和脑源性神经营养因子有关。帕金森与抑郁存在共有的神经生物学机制,故中医药治疗帕金森伴抑郁可能具有双重调节作用。

Parkinson’s disease with depression belongs to the category of "tremor syndrome" and "depression syndrome" of Traditional Chinese Medicine. Its syndrome characteristics and distribution are different from simple tremor syndrome and depression syndrome. Its neuroplastic mechanism involves dopamine, serotonin, norepinephrine and brain-derived neurotrophic factor. Parkinson’s disease and depression have common neuro-biological mechanisms. Therefore, Chinese medicine treatment of Parkinson’s disease with depression may have a dual regulation effect.