摘要
帕金森伴抑郁属于中医"颤证"与"郁证"合病范畴,其证候特征及证型分布与单纯颤证、郁证有所不同,其神经可塑性机制涉及多巴胺、五羟色胺、去甲肾上腺素和脑源性神经营养因子有关。帕金森与抑郁存在共有的神经生物学机制,故中医药治疗帕金森伴抑郁可能具有双重调节作用。
Parkinson’s disease with depression belongs to the category of "tremor syndrome" and "depression syndrome" of Traditional Chinese Medicine. Its syndrome characteristics and distribution are different from simple tremor syndrome and depression syndrome. Its neuroplastic mechanism involves dopamine, serotonin, norepinephrine and brain-derived neurotrophic factor. Parkinson’s disease and depression have common neuro-biological mechanisms. Therefore, Chinese medicine treatment of Parkinson’s disease with depression may have a dual regulation effect.
作者
吴芊
吴佳佳
邱文琪
严志祎
陈家旭
刘玥芸
薛哲
Wu Qian;Wu Jiajia;Qiu Wenqi;Yah Zhiyi;Chen Jiaxu;Liu Wei;Xue Zhe(School of Basic Medical Science,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2018年第11期1964-1968,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上资助项目(81473597):肝郁脾虚型抑郁症海马-杏仁核神经活性甾体变化及逍遥散的作用机理
负责人:陈家旭
关键词
帕金森
抑郁
证候
神经可塑性
Parkinson's disease
depression
syndrome
neuroplasticity