藏药毛诃子水溶性化学成分研究

Study on Water-Soluble Constituents from Tibetan Medicine Terminalia billirica(Gaert.) Roxb

目的:研究藏药毛诃子Terminalia billirica(Gaert.) Roxb.水溶性部分化学成分。方法:利用大孔吸附树脂Diaion HP-20、凝胶Sephadex LH-20、Toyopearl HW-40、MCI gel CHP 20P、和ODS多种色谱技术分离纯化,根据化合物理化性质和波谱学数据进行结构鉴定。结果:从毛诃子水溶性部位分离得到10个化合物,分别鉴定为柯里拉京(Corilagin,1)、水杨苷(Salicoside,2)、甲基-α-阿拉伯糖苷(Methyl-α-D-arabinofuranoside,3)、1,4-二甲基-β-D-吡喃果糖(1,4-dimethyl-β-D-fructopyranose,4)、β-吡喃果糖(β-fructopyranose,5)和β-呋喃果糖(β-fructofuranose,6)、没食子酸(Gallic acid,7)、鞣花酸(Ellagic acid,8)1,2,3,4,6-五-O-没食子酰基-β-D-葡萄糖吡喃苷(1,2,3,4,6-penta-O-galloyl-β-D-glucopyranonside,9)、诃黎勒酸(Chebulagic acid,10)。结论:除化合物7和8外,其余均为首次从该植物中分离得到,化合物2-6为首次从榄仁树属植物中得到。

This paper aimed at investigating the water-soluble constituents of Terminalia billirica(Gaert.) Roxb.Compounds were isolated and purified by Diaion HP-20, Sephadex LH-20, Toyopearl HW-40, MCI gel CHP 20 P and ODS column chromatographies. The chemical structures were elucidated according to spectral data and physicochemical properties. The results showed that ten compounds were isolated and identified as corilagin, salicoside, methyl-α-Darabinofuranoside, 1,4-dimethyl-β-d-fructopyranose, β-fructopyranose, β-fructofuranose gallic acid, ellagic acid, 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranonside, Chebulagic acid. Except compound 7 and 8,others compounds are separated from Terminalia billirica(Gaert.) Roxb for the first time, and except corilgin, the other compounds are separated from Terminalia for the first time.