腹腔镜对结直肠癌患者血清基质金属蛋白酶、胃肠激素及应激激素水平的影响

Effects of Laparoscopy on the Serum Levels of Matrix Metalloproteinases,Gastrointestinal Hormones and Stress Hormones in Patients with Colorectal Cancer

目的:探讨腹腔镜对结直肠癌患者血清基质金属蛋白酶、胃肠激素及应激激素水平的影响。方法:将110例结直肠癌患者纳入本研究,随机分为对照组和观察组,均55例,分别给予对照组和观察组患者开腹手术治疗和腹腔镜手术治疗,对比治疗前后患者的血清基质金属蛋白酶、胃肠激素及应激激素水平。结果:治疗前,两组血清基质金属蛋白酶(Matrix metalloproteinase,MMP)MMP-2、MMP-9、血清胃动素(Motilin,MTL)、胃泌素(Gastrin,GAS)、皮质醇(Cortisol,Cor)、去甲肾上腺素(Noradrenaline,NE)水平比较差异均无统计学意义(P>0.05);与组内治疗前相比,两组治疗后血清MMP-2、MMP-9、MTL、GAS水平均显著降低,血清COR、NE水平均显著升高,差异有统计学意义(P<0.05);观察组治疗后血清MMP-2、MMP-9、NE、COR水平均明显低于对照组,血清GAS、MTL水平均明显高于对照组,差异对比均有显著性(P<0.05)。结论:腹腔镜治疗结直肠癌可有效降低患者血清基质金属蛋白酶水平,促进胃肠功能恢复,减轻机体应激损伤。

Objective:To investigate the effects of laparoscopy on the serum levels of matrix metalloproteinases, gastrointestinal hormones and stress hormones in patients with colorectal cancer. Methods: 110 cases of colorectal cancer patients were selected as the research object, based on the random data table method they were divided into control group and observation group, 55 cases in each group, the control group were treated with open surgery, observation group were treated with laparoscopic surgery, before and after treatment the serum levels of matrix metalloproteinases, gastrointestinal hormones and stress hormone of the two groups were compared.Re sults: There was no significant difference in the serum levels of matrix metalloproteinase(MMP, MMP-2, MMP-9), motilin(MTL),gastrin(GAS), cortisol(Cor) and noradrenaline(NE) between the two groups before the treatment(P>0.05). Compared with levels in the group before treatment, after treatment, the serum levels of MMP-2, MMP-9, MTL and GAS in the two groups were significantly decreased, and the serum levels of COR and NE were significantly increased, differences was statistically significant(P<0.05). After treatment, the serum levels of MMP-2, MMP-9, NE and COR in the observation group were significantly lower than those in the control group, and the serum GAS, MTL levels were significantly higher than those in the control group, all the difference between the two groups was significant(P<0.05). Conclusion: Laparoscopic treatment of colorectal cancer can effectively reduce the sreum levels of matrix metalloproteinases, promote the recovery of gastrointestinal function and relieve the level of stress hormones, which has certain clinical value.