醋酸亮丙瑞林对子宫内膜异位症患者血清雌二醇、孕酮及黄体生成素水平的影响

Efficacy of Leuprolide Acetate in the Treatment of Patients with Endometriosis and Its Effects on the Serum Estradiol, Progesterone and Luteinizing Hormone Levels

目的:研究醋酸亮丙瑞林对子宫内膜异位症患者血清雌二醇、孕酮及黄体生成素水平的影响。方法:选取2016年10月至2017年9月我院收治的84例子宫内膜异位症患者,根据患者入院顺序分为观察组和对照组,每组42例。观察组使用醋酸亮丙瑞林治疗,对照组使用炔雌醇环丙孕酮片。比较两组患者的临床疗效,治疗前后痛经评分、血清雌二醇、孕酮、黄体生成素、TGF-β、IL-4、IL-10、IL-17水平的班花及不良反应的发生情况。结果:治疗后,观察组临床总有效率显著高于对照组[90.48%(38/42) vs.64.29%(27/42)](P<0.05)。两组患者治疗后痛经评分、雌二醇、孕酮、黄体生成素、TGF-β、IL-4及IL-10水平均较治疗前显著降低(P<0.05),且观察组以上指标均明显低于对照组(P<0.05)。两组患者治疗后血清IL-17水平及不良反应发生率与治疗前相比均无明显差异(P>0.05)。结论:与炔雌醇环丙孕酮片相比,醋酸亮丙瑞林能有效提高子宫内膜异位症患者的临床疗效,降低其血清雌二醇、孕酮及黄体生成素水平,改善患者的痛经情况,且安全性较高。

Objective:To study the effects of leuprolide acetate on the serum estradiol,progesterone and luteinizing hormone levels in patients with endometriosis.Methods:Eighty-four patients with endometriosis admitted in our hospital from August 2015 to July2016 were enrolled.The patients were divided into the observation group and the control group according to the patient admission order,with 42 cases in each group.The observation group was treated with leuprolide acetate,and the control group was treated with ethinyl estradiol cyproterone tablets.The clinical efficacy,incidence of dysmenorrhea,changes of serum estradiol,progesterone,luteinizing hormone,TGF-b,IL-4,IL-10,IL-17 levels before and after treatment and incidnece of adverse reactionswere compared Between two groups.Results:After treatment,the total clinical effective rate of observation group was significantly higher than that of the control group[90.48%(38/42)vs.64.29%(27/42)](P<0.05).The dysmenorrhea scores,estradiol,progesterone,luteinizing hormone,TGF-β,IL-4 and IL-10 levels of both groups were significantly lower than those before treatment(P<0.05),and the above indicators were obviously lower in the observation group lower than those of the control group(P<0.05).There was no significant difference in the serum IL-17 levels and incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion:Compared with ethinyl estradiol cyproterone tablets,leuprolide acetate can effectively improve the clinical efficacy of patients with endometriosis,reduce the serum estradiol,progesterone and luteinizing hormone levels,improve patients’condition of dysmenorrhea with high safety.