膀胱出口部分梗阻动物模型的研究进展

Research Progress on Animal Model of Partial Bladder Outlet Obstruction

构建理想的膀胱出口部分梗阻(pBOO)动物模型是研究膀胱梗阻性疾病发病机制和开展药物治疗研究的关键。本文就pBOO动物模型的诱导方式选择(包括经耻骨上膀胱颈结扎法、尿道外口缝扎法、尿道外口皮下注射透明质酸等),及诱导pBOO动物模型的特点及局限性进行综述。

Constructing an ideal animal model of bladder outlet partial obstruction(pBOO) is the key to study the pathogenesis of bladder obstructive diseases and conduct drug therapy research.In this article,we summarized the animal model induction methods,including the characteristics and limitations of animal models induced by suprapubic bladder neck ligation,extraurethral splenic suture,and subcutaneous hyaluronate injection outside the urethra,and the characteristics and disadvantages of induced pBOO model.