老年女性血清胆红素水平与颈动脉粥样硬化的关系

Relationship between carotid atherosclerosis and serum bilirubin in elderly women

目的研究老年女性颈动脉粥样硬化与血清胆红素水平的关系。方法回顾性分析2015年1月-2017年12月中国人民武装警察部队总医院干部病房96例60岁以上老年女性患者的临床资料,所有患者均行颈部血管超声检查,依据是否存在颈动脉粥样硬化分为研究组及对照组,其中颈动脉粥样硬化组再分为有无斑块两个亚组。测定各组患者血清胆红素水平,之后进行对比分析及相关分析。结果颈动脉粥样硬化组血清总胆红素显著低于对照组,2组间比较差异有统计学意义(P<0.05)。校正年龄、血脂、糖尿病、高血压病等危险因素后,血清胆红素水平和颈动脉粥样硬化呈负相关关系。结论血清胆红素水平偏低是老年女性颈动脉粥样硬化的独立危险因素。

Objective To study the relationship between carotid atherosclerosis and serum bilirubin level in elderly women.Methods 96 female patients with (69.6±6.1)(60-89)years old,all postmenopausal,underwent ultrasonography of carotid artery.64 were diagnosed as with carotid atherosclerosis (arteriosclerosis group),and 32 without carotid atherosclerosis (non-arteriosclerosis group).The arteriosclerosis group was re-divided into 2 subgroups:plaque subgroup (n=47)and subgroup without plaque (n=17).Fasting peripheral venous blood samples were collected to examine the levels of total bilirubin (TB),direct bilirubin (DB),indirect bilirubin (IB),triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterin (LDL-C),high density lipoprotein cholesterin (HDL-C),hemoglobin (HGB),red blood cell (RBC),and white blood cell (WBC).Results The levels of TB,DB,all significantly lower than those of the non-arteriosclerosis group (all P <0.05).There were no significant differences in the levels of TB,DB,and IB between the subgroups with and without plaque (all P >0.05).Levels of TG,TC,LDL-C, and HDL-C were not correlated to carotid atherosclerosis.After adjusting for age,blood lipids,diabetes,hypertension and other risk factors,the serum bilirubin leveI was negatively correlated with carotid atherosclerosis.Conclusion Low blood serum bilirubin level is a risk fector for carotid atherosclerosis in postmenopausal women.