基于数据挖掘分析FOXO1在成熟B细胞肿瘤中的表达及靶基因预测

The analysis of FOXO1 in mature B-cell neoplasms and its target genes based on data mining

目的:利用数据挖掘分析FOXO1在B细胞肿瘤中的表达情况,并进一步探讨FOXO1对B细胞肿瘤的影响。方法:利用Oncomine数据库分析FOXO1基因在B细胞肿瘤中mRNA水平的变化。通过BIOGPS分析人体正常组织和其相应的肿瘤组织中FOXO1基因的表达差异。利用GEPIA做FOXO1基因的表达水平与B细胞肿瘤患者生存期的相关性分析。在String-DB数据库中探索FOXO1基因在细胞信号转导通路中的位置以及与其关系密切的上下游基因。结果:与正常组织相比,B细胞肿瘤组织中FOXO1基因在mRNA水平呈低表达,FOXO1基因的表达水平与B细胞肿瘤患者的总体生存时间无明显相关性(Log-rank P=0.39)。EP300、JUN、MYC、STAT1、FOS、SPI1、E2F1等基因与FOXO1有明显或潜在的相互作用。结论:大样本数据挖掘能迅速获取B细胞肿瘤组织中FOXO1表达的相关信息,为探索FOXO1在B细胞肿瘤发生发展中的作用提供科学的理论基础。

Objective:To explore the expression and significance of FOXO1 in mature B-cell neoplasms. Methods:The expression of FOXO1 in mature B-cell neoplasms was mined in Oncomine database. The different expressions of FOXO1 between the normal tissue and B-cell neoplasms were analyzed by BIOGPS database. The survival time of patients with mature B-cell neoplasms was detected by GEPIA. The FOXO1 interacting proteins were analyzed by String-DB database. Results:At the mRNA level,FOXO1 was lower in mature B-cell neoplasms than in normal tissue,and the expression level was not notable correlated with the prognosis of mature B-cell neoplasms(Logrank P=0.39). FOXO1 related proteins are EP300、JUN、MYC、STAT1、FOS、SPI1、E2 F,etc.Conclusion:The information of FOXO1 expression in mature B-cell neoplasms could be quickly extracted by using data mining and would be an scientific and theoretical support for the further research.