太原地区汉族冠心病患者CYP2C19基因多态性研究

Analysis of CYP2C19 genetic polymorphism in some patients of Han nationality with coronary heart disease in Taiyuan area

目的探讨太原地区汉族冠心病患者CYP2C19基因多态性,为氯吡格雷个体化用药提供参考。方法选取2017年10月—2018年12月在山西省心血管病医院就诊的787例冠心病患者作为研究对象,进行CYP2C19基因多态性检测。结果 787例汉族冠心病患者基因型*1/*17、*17/*17、*1/*1、*1/*2、*1/*3、*2/*17、*2/*2、*2/*3、*3/*3频率分别为2.29%、0%、42.95%、38.75%、5.34%、0.51%、6.23%、3.43%、0.51%,其中CYP2C19超快代谢型18例(2.29%)、快代谢型338例(42.95%)、中间代谢型351例(44.60%)及慢代谢型80例(10.17%)。结论太原地区汉族冠心病患者基因型以CYP2C19*1/*1为主,代谢表型以中间代谢型为主,代谢表型、基因型分布与其他地区汉族基本一致,代谢表型分布与蒙古族、回族有差异。

Objective To analyze the distribution of genetic polymorphism of CYP2C19 gene in some patients of Han nationality with coronary heart disease(CHD) in Taiyuan, in order to provide reference for the individualized treatment of Clopidogrel. Methods The CYP2C19 genotypes of 787 patients with coronary heart disease in October 2017 to December 2018 were determined, and the distribution of frequencies of metabolic phenotypes were counted and compared between Taiyuan and other regions or other nations. Results The genotypes of 787 Han nationality patients with coronary cardiac diseases were *1/*17, *17/*17, *1/*1, *1/*2, *1/*3, *2/*17, *2/*2, *2/*3, *3/*3, and their frequencies were 2.29%, 0%, 42.95%, 38.75%, 5.34%, 0.51%, 6.23%, 3.43%, 0.51%, respectively;among them, 18 CYP2C19 patients(2.29%) had ultra-fast metabolic phenotype, 338 cases(42.95%) showed fast metabolism, 351 cases(44.60%) were of intermediate metabolism and 80 cases(10.17%) with slow metabolism. Conclusions CYP2C19*1/*1 is the main genotype of CHD patients in the Han nationality in Taiyuan, and intermediate metabolic phenotype is the main one. The distribution of metabolic phenotype and genotype is basically consistent with that of Han nationality in other regions, and the metabolic phenotypes between Han and Mongolian, Hui were different from each other.