肝功能和血脂指标在脂肪肝患者诊断中的应用价值

Diagnostic value of liver function and blood lipid indexes in patients with fatty liver

目的探讨肝功能和血脂指标检测在脂肪肝患者诊断中的应用价值。方法选择2017年6月—2018年8月德州市运河经济开发区运河街道办事处卫生院收治的40例脂肪肝患者作为脂肪肝组,另选40例接受体检的健康体检人群作为健康对照组。采用日立7600全自动生化分析仪检测所有受检者的肝功能指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)]和血脂指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)],对两组检测结果进行对比分析。结果与健康对照组比较,脂肪肝组的ALT、AST、TG、TC均明显升高[ALT(U/L):54.65±1.02比26.13±1.21,AST(U/L):80.98±1.17比39.22±1.34,TG(mmol/L):2.69±0.31比1.02±0.21、TC(mmol/L):6.99±1.64比4.13±1.67,均P<0.05]。两组的HDL-C、LDL-C比较差异均无统计学意义(均P>0.05)。结论肝功能指标和血脂指标检测在脂肪肝患者诊断中有较高的应用价值,能够为患者后期治疗提供有利依据,值得进一步研究。

Objective To investigate the application value of liver function and blood lipid index tests in the diagnosis of fatty liver patients. Methods Forty patients with fatty liver who were admitted to the hospital in the Canal Street Office of Dezhou Canal Economic Development Zone from June 2017 to August 2018 were selected as the fatty liver group. Another 40 healthy people who underwent physical examination were selected as healthy controls. Hitachi 7600 automatic biochemical analyzer was used to detect liver function indexes [alanine aminotransferase(ALT), aspartate aminotransferase(AST)] and blood lipid indexes [triglyceride(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C)], and the results of two groups were compared and analyzed. Results Compared with healthy controls, ALT, AST, TG and TC were significantly higher in the fatty liver group [ALT(U/L): 54.65±1.02 vs. 26.13±1.21, AST(U/L): 80.98±1.17 vs. 39.22±1.34, TG(mmol/L): 2.69±0.31 vs. 1.02±0.21, TC(mmol/L): 6.99±1.64 vs. 4.13±1.67, all P < 0.05]. There were no statistical significant differences in HDL-C and LDL-C between the two groups(all P > 0.05). Conclusion The detections of liver function and blood lipid indexes have a high application value in the diagnosis of fatty liver patients, which can provide a favorable basis for patients’ late treatment and deserve further study.