中药干预肿瘤患者放化疗中免疫功能临床研究进展

Research Progress of Intervention of Chinese Herbal Medicine on Immune Function of Tumor Patients Undergoing Radiotherapy and Chemotherapy

随着中药干预肿瘤患者放化疗中免疫功能的相关研究越来越深入,对其作用机制、治则治法的研究也是多方面的。作用机理研究多着眼于肿瘤微环境的调节、肿瘤血管生成的抑制、肿瘤细胞增殖有效控制以及对肿瘤细胞诱导凋亡等方面。在临床治疗中常用的治则治法有扶正固本、活血化瘀、清热解毒、消痰散结等。对中药单体抗肿瘤机制的研究众多,关于中药抗癌成分的研究,常见的有中药多糖、人参皂苷Rg3、苦参碱等,而以扶正培本为主导的中药复方制剂在肿瘤治疗中的应用最为广泛。

With the deepening of researches on the intervention of Chinese herbal medicine on the immune function of tumor patients undergoing radiotherapy and chemotherapy,there are also many studies on its mechanism of action,therapeutic principles and treatments.Studies on mechanism of action mainly focus on the regulation of tumor microenvironment,inhibition of tumor angiogenesis,effective control of tumor cell proliferation and induction of apoptosis of tumor cells.The commonly used therapeutic principles and treatments in clinical practice include:supporting vital qi and consolidating root,invigorating blood and dissolving stasis,clearing heat and resolving toxins,dispersing phlegm and dissipating masses,etc.There are many studies on the anti-tumor mechanism of Chinese herbal monomers,and the researches on the anti-tumor components of Chinese herbal medicine are common,such as Chinese herbal polysaccharides,ginsenosides Rg3,and matrine,etc.,while the Chinese herbal compound formulations led by the principle of supporting vital qi and consolidating root are most widely used in the treatment of tumor.