归脾汤治疗肾性贫血临床研究

Clinical Study of Guipi Tang for Renal Anemia

目的:分析归脾汤在肾性贫血的临床应用效果。方法:选择接受血液透析治疗的肾性贫血患者60例,按照随机数字表法将患者分成对照组和观察组,各30例。对照组患者口服多糖铁复合物,观察组服用归脾汤,比较2组患者血清铁及铁蛋白含量,应用生活质量指数自评量表(SF-36)评分以及日常活动能力调查表(ADL)评分评价治疗效果。结果:观察组总依从率为93.33%,显著高于对照组的73.33%,差异有统计学意义(P <0.05)。治疗前,2组血生化指标及微型营养评分、生活质量SF-36各维度评分、ADL评分、焦虑自评量表(SAS)评分及抑郁自评量表(SDS)评分比较,差异均无统计学意义(P> 0.05)。治疗后,2组血红蛋白、血清铁、铁蛋白均较治疗前升高(P <0.05);观察组血红蛋白、血清铁、铁蛋白均高于对照组(P <0.05)。治疗后,2组生活质量SF-36各维度评分均较治疗前升高(P <0.05);观察组生活质量SF-36各维度评分均高于对照组(P <0.05)。治疗后,2组ADL生活质量评分均较治疗前升高(P <0.05),观察组ADL评分高于对照组(P <0.05)。治疗后,2组SAS评分及SDS评分较治疗前显著降低(P <0.05);观察组SAS评分及SDS评分低于对照组(P <0.05)。结论:归脾汤在肾性贫血的临床应用效果良好。

Objective:To observe the clinical application effect of Guipi tang for renal anemia. Methods:Selected 60 cases of patients with renal anemia who received hemodialysis for treatment, and divided them into the control group and the observation group randomly,30 cases in each group. The control group received the oral administration of polysaccharide-iron complex,while the observation group received the oral administration of Guipi tang. Compared the content of serum iron and hemoglobin of patients in both groups,and evaluated the clinical effect via scores of 36-item short form health survey(SF-36)and questionnaire of activities of daily living(ADL). Results:The total compliance rate was 93.33% in the observation group,being significantly higher than 73.33% in the control group, difference being significant(P < 0.05). Before treatment,comparing the biochemical indexes of blood,scores of mini nutritional assessment,SF-36 scores in all dimensions,ADL scores,scores of self-rating anxiety scale(SAS) and self-rating depression scale(SDS) in-between the two groups,there were no significant differences being found(P > 0.05). After treatment,the content of hemoglobin,serum iron and ferritin in both groups was respectively higher than that before treatment(P < 0.05);the content of hemoglobin,serum iron and ferritin in the observation group was respectively higher than that in the control group(P < 0.05). After treatment,SF-36 scores in all dimensions of both groups were higher than those before treatment(P < 0.05);the SF-36 scores in all dimensions of the observation group were higher than those in the control group(P < 0.05). After treatment,ADL scores in both groups were higher than those before treatment(P < 0.05);the ADL scores in the observation group were higher than those in the controlgroup(P < 0.05). After treatment,scores of SAS and SDS in both groups were significantly lower than those before treatment(P < 0.05);the scores of SAS and SDS in the observation group were lower than those in the control group(P < 0.05).Conclusion:Guipi tang has good clinical application effect in treating renal anemia.